bretylium has been researched along with Lupus Erythematosus, Systemic in 2 studies
bretylium: RN given refers to parent cpd
bretylium : A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bretylium was without any effect on these parameters." | 1.27 | Effect of captopril on murine systemic lupus erythematosus disease. ( Herlitz, H; Svalander, C; Tarkowski, A; Westberg, G, 1988) |
| "The bretylium-treated animals also exhibited an improved renal pathology index but they did not differ from the controls with respect to proteinuria and hematuria." | 1.27 | Beneficial effect of captopril on systemic lupus erythematosus-like disease in MRL lpr/lpr mice. ( Herlitz, H; Svalander, C; Tarkowski, A; Volkmann, R; Westberg, G, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herlitz, H | 2 |
| Svalander, C | 2 |
| Tarkowski, A | 2 |
| Westberg, G | 2 |
| Volkmann, R | 1 |
2 other studies available for bretylium and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Effect of captopril on murine systemic lupus erythematosus disease.
Topics: Animals; Blood Pressure; Bretylium Compounds; Captopril; Enalapril; Hypertension; Lupus Erythematosu | 1988 |
Beneficial effect of captopril on systemic lupus erythematosus-like disease in MRL lpr/lpr mice.
Topics: Animals; Blood Pressure; Bretylium Compounds; Captopril; Cyclophosphamide; Dermatitis; Female; Lupus | 1988 |