Compounds > bretylium
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bretylium and Hypertension

bretylium has been researched along with Hypertension in 13 studies

bretylium: RN given refers to parent cpd
bretylium : A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Bretylium was without any effect on these parameters."1.27Effect of captopril on murine systemic lupus erythematosus disease. ( Herlitz, H; Svalander, C; Tarkowski, A; Westberg, G, 1988)
"Pretreatment with reserpine regularly depressed or abolished the hypertensive response to eserine."1.24Factors influencing the hypertensive effect of eserine in the rat. ( LESIC, R; VARAGIC, V, 1961)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199011 (84.62)18.7374
1990's2 (15.38)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
AVIADO, DM1
HEYMER, A1
NIESEL, P1
OBERHOFFER, G1
LESIC, R1
VARAGIC, V1
FIFE, R1
MORAN, F1
PRINEAS, J1
DAY, MD1
RAND, MJ1
GESSA, GL1
ABERT, E1
WASYLUK, J1
KIRKENDALL, WM1
WILSON, WR1
Nand, V1
Doggrell, SA1
Boura, AL1
Taddei, S1
Salvetti, A1
Pedrinelli, R1
Herlitz, H2
Svalander, C2
Tarkowski, A2
Westberg, G2

Other Studies

13 other studies available for bretylium and Hypertension

ArticleYear
Sympathetic nerve blocking drugs for the treatment of hypertension. TM-10, beta TM-10, bretylium and guanethidine.
    The American journal of the medical sciences, 1961, Volume: 241

    Topics: Antihypertensive Agents; Bretylium Compounds; Choline; Guanethidine; Hypertension

1961
[On the therapy of hypertension with bretylium (darenthin, bretylin) and guanethidine (ismelin). (Comparative clinical-statistical evaluation)].
    Die Medizinische Welt, 1960, Aug-06, Volume: 32

    Topics: Amidines; Antihypertensive Agents; Biometry; Bretylium Compounds; Guanethidine; Hypertension

1960
Factors influencing the hypertensive effect of eserine in the rat.
    British journal of pharmacology and chemotherapy, 1961, Volume: 16

    Topics: Adrenal Glands; Animals; Blood Pressure; Bretylium Compounds; Choline; Epinephrine; Hypertension; No

1961
Treatment of hypertension in out-patients: mecamylamine, bretylium and guanethidine.
    Scottish medical journal, 1962, Volume: 7

    Topics: Bretylium Compounds; Guanethidine; Hypertension; Mecamylamine; Outpatients

1962
Antagonism of guanethidine and bretylium by various agents.
    Lancet (London, England), 1962, Dec-15, Volume: 2, Issue:7268

    Topics: Bretylium Compounds; Cocaine; Guanethidine; Hypertension; Methylphenidate; Monoamine Oxidase Inhibit

1962
[BRETYLIUM-LIKE ACTION OF A MONOAMINE OXIDASE INHIBITOR].
    Bollettino della Societa italiana di biologia sperimentale, 1963, Sep-15, Volume: 39

    Topics: Adrenalectomy; Animals; Bretylium Compounds; Cats; Dogs; Ganglionic Blockers; Hypertension; Monoamin

1963
[BRETYLIUM TOLUENE SULFATE IN THE TREATMENT OF ARTERIAL HYPERTENSION].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1965, Jan-25, Volume: 20

    Topics: Bretylium Compounds; Humans; Hypertension; Sulfates; Sulfur Oxides; Toluene

1965
Pharmacodynamics and clinical use of guanethidine, bretylium and methyldopa.
    The American journal of cardiology, 1962, Volume: 9

    Topics: Amidines; Antitubercular Agents; Bretylium Compounds; Dihydroxyphenylalanine; Guanethidine; Humans;

1962
Effects of tetraethylammonium, 4-aminopyridine and bretylium on cardiovascular tissues from normo- and hypertensive rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:5

    Topics: 4-Aminopyridine; Action Potentials; Animals; Arteries; Bretylium Compounds; Cardiovascular System; H

1999
History of research into hypertension.
    Journal of the Royal Society of Medicine, 1992, Volume: 85, Issue:8

    Topics: Bretylium Compounds; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; History, 20th Cent

1992
Persistence of sympathetic-mediated forearm vasoconstriction after alpha-blockade in hypertensive patients.
    Circulation, 1989, Volume: 80, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adult; Bretylium Compounds; Dose-Response Relationship, Drug; Female;

1989
Influence of antihypertensive treatment on renal and extrarenal lupus manifestations in MRL/l mice.
    Scandinavian journal of urology and nephrology. Supplementum, 1988, Volume: 108

    Topics: Animals; Blood Pressure; Bretylium Compounds; Captopril; Enalapril; Female; Hypertension; Lupus Neph

1988
Effect of captopril on murine systemic lupus erythematosus disease.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1988, Volume: 6, Issue:4

    Topics: Animals; Blood Pressure; Bretylium Compounds; Captopril; Enalapril; Hypertension; Lupus Erythematosu

1988