bretylium has been researched along with Arrhythmias, Cardiac in 12 studies
bretylium: RN given refers to parent cpd
bretylium : A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recently, amiodarone has been shown to be rapidly effective in suppressing sustained, incessant ventricular tachycardia and ventricular fibrillation in this setting." | 7.68 | Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs. ( Horrigan, TP; Mostow, ND; Noon, DL; Rosalion, A; Snow, NJ, 1991) |
| "Bretylium, with an extensive pharmacologic and medicinal history, was approved by the United States Food and Drug Administration in 1986 for "short-term prevention and treatment of ventricular fibrillation (VF) and treatment of life-threatening ventricular arrhythmias and ventricular tachycardia (VT) unresponsive to adequate doses of a first-line antiarrhythmic agent, such as lidocaine." | 3.96 | Bretylium, a Class III Antiarrhythmic, Returns to the Market. ( Kowey, PR; Sullivan, RM; Thind, M; Williams, RN, 2020) |
| " To prevent arrhythmias, bretylium (5 mg/kg) was administered intravenously 10 minutes before catheter manipulation and repeated every 30 minutes throughout the procedure." | 3.68 | Prophylactic treatment of swine with bretylium for experimental cardiac catheterization. ( Gaymes, CH; Gillette, PC; Harold, ME; Schumann, RE; Swindle, MM, 1993) |
| " Recently, amiodarone has been shown to be rapidly effective in suppressing sustained, incessant ventricular tachycardia and ventricular fibrillation in this setting." | 3.68 | Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs. ( Horrigan, TP; Mostow, ND; Noon, DL; Rosalion, A; Snow, NJ, 1991) |
| " Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions." | 2.42 | Potentially significant drug interactions of class III antiarrhythmic drugs. ( DeBisschop, M; Lower, DL; Martin, LG; Yamreudeewong, W, 2003) |
| "Cardiac arrhythmias frequently respond only to drugs that have as their predominant electrophysiologic effect the prolongation of repolarization and refractoriness." | 2.40 | Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs. ( Bharucha, D; Kowey, PR; Marinchak, RA; Rials, SJ, 1997) |
| "Cardiac arrhythmias arise from abnormalities of impulse initiation or impulse conduction or both." | 2.37 | Antiarrhythmic drugs: electrophysiological basis of their clinical usage. ( Moulder, PV; Smith, DE; Weng, JT, 1986) |
| "The frequency of ventricular arrhythmias increases with age." | 2.37 | Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. ( Morganroth, J; Nestico, PF, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Thind, M | 1 |
| Sullivan, RM | 1 |
| Williams, RN | 1 |
| Kowey, PR | 2 |
| Yamreudeewong, W | 1 |
| DeBisschop, M | 1 |
| Martin, LG | 1 |
| Lower, DL | 1 |
| Schumann, RE | 1 |
| Harold, ME | 1 |
| Gillette, PC | 1 |
| Swindle, MM | 1 |
| Gaymes, CH | 1 |
| Marinchak, RA | 1 |
| Rials, SJ | 1 |
| Bharucha, D | 1 |
| von Planta, M | 1 |
| Chamberlain, D | 1 |
| Rosalion, A | 1 |
| Snow, NJ | 1 |
| Horrigan, TP | 1 |
| Noon, DL | 1 |
| Mostow, ND | 1 |
| Weng, JT | 1 |
| Smith, DE | 1 |
| Moulder, PV | 1 |
| Coker, SJ | 1 |
| Podrid, PJ | 1 |
| Grubb, BP | 1 |
| Nestico, PF | 1 |
| Morganroth, J | 1 |
| Kasten, GW | 1 |
| Martin, ST | 1 |
4 reviews available for bretylium and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Potentially significant drug interactions of class III antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Drug Interactions; Hu | 2003 |
Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Phenethylamin | 1997 |
Antiarrhythmic drugs: electrophysiological basis of their clinical usage.
Topics: Action Potentials; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atriov | 1986 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digox | 1986 |
8 other studies available for bretylium and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Bretylium, a Class III Antiarrhythmic, Returns to the Market.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Product Recalls and Withd | 2020 |
Prophylactic treatment of swine with bretylium for experimental cardiac catheterization.
Topics: Animals; Arrhythmias, Cardiac; Bretylium Compounds; Cardiac Catheterization; Swine; Swine, Miniature | 1993 |
Drug treatment of arrhythmias during cardiopulmonary resuscitation. A statement for the Advanced Life Support Working Party of the European Resuscitation Council.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Atropine; Bretylium Compounds; Calcium; Cardiopulmonary R | 1992 |
Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Blood Pressure; Bretylium Compounds; Dogs; Drug Evaluatio | 1991 |
Anesthetized rabbit as a model for ischemia- and reperfusion-induced arrhythmias: effects of quinidine and bretylium.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Bretylium Compounds; Coronary Disease; Coronary Vessels; | 1989 |
Antiarrhythmic drug therapy (Part 1). Benefits and hazards.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compou | 1985 |
Long-term antiarrhythmia therapy.
Topics: Arrhythmias, Cardiac; Bretylium Compounds; Humans; Male; Time Factors | 1989 |
Bupivacaine cardiovascular toxicity: comparison of treatment with bretylium and lidocaine.
Topics: Animals; Arrhythmias, Cardiac; Bretylium Compounds; Bupivacaine; Dogs; Electrocardiography; Heart Ve | 1985 |