Page last updated: 2024-08-24

brequinar and Neoplasms

brequinar has been researched along with Neoplasms in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's8 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (6.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Kadir, MFA; Nellore, K; Othman, S1
Fang, B; Gan, B; Koppula, P; Lee, H; Lei, G; Liu, X; Mao, C; Olszewski, K; Poyurovsky, MV; Wu, S; Yan, Y; Zhang, Y; Zhuang, L1
Peters, GJ1
Buzaid, AC; Hait, WN; Marsh, JC; Murren, JR; Pizzorno, G; Poo, WJ; Ravikumar, TS; Strair, RK; Todd, M1
Adams, DB; Agra, AM; Bertino, JR; Chi, CL; Currie, VE; King, SY; Pieniaszek, HJ; Quon, CY; Shen, HS1
Awada, A; Brentzel, J; Brown, TD; Burris, HA; King, SY; Kuhn, JG; Lynch, W; O'Rourke, TJ; Raymond, E; Von Hoff, DD1
Brown, TD; Burris, HA; Havlin, KA; O'Rourke, TJ; Rodriguez, GI; Wall, JG; Weiss, GR1
Diasio, RB; Stagg, MP1
Laurensse, EJ; Nadal, JC; Peters, GJ; Pinedo, HM; Schwartsmann, G; van der Vijgh, WJ; van Groeningen, CJ1
Dodion, P; Gall, H; Joggi, J; Schwartsmann, G; Simonetti, G; ten Bokkel Huinink, WW; van der Vijgh, WJ; van Hennik, MB; Vermorken, JB; Winograd, B1
Abeloff, MD; Adams, DB; Clarke, BV; Ettinger, DS; Grochow, LB; Hantel, A; McGuire, WB; Noe, DA; Rowinsky, EK; Shen, HS1
Armand, JP; Bork, E; Dodion, P; Nieboer, C; Pinedo, HM; Schwartsmann, G; Seldenrijk, CA; ten Bokkel Huinink, WW; Vermorken, JB1
Bork, E; Hansen, HH; Vest, S1
Crespeigne, N; Dodion, P; Gall, H; Joggi, G; Klein, I; Schwartsmann, G; ten Bokkel Huinink, WW; van der Vijgh, WJ; van Hennik, MB; Vermorken, JB1
Arteaga, CL; Beougher, K; Brentzel, HJ; Brown, TD; Kuhn, JG; O'Rourke, TJ; Shen, HS; Von Hoff, DD; Weiss, GR1
Boven, E; Fodstad, O; Lobbezoo, MW; Pinedo, HM; Winograd, B1

Reviews

2 review(s) available for brequinar and Neoplasms

ArticleYear
New anticancer agents.
    Cancer chemotherapy and biological response modifiers, 1991, Volume: 12

    Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Biphenyl Compounds; Chrysenes; Deoxycytidine; Echinomycin; Epirubicin; Etanidazole; Flavonoids; Gemcitabine; Guanidines; Humans; Idarubicin; Menogaril; Mitoguazone; Neoplasms; Nitroimidazoles; Nogalamycin; Organoplatinum Compounds; Paclitaxel; Pentostatin; Polymers; Propylene Glycols; Ribavirin; Sulfonylurea Compounds; Trimetrexate; Vidarabine Phosphate

1991
Novel chemotherapeutic agents in early clinical development.
    Current opinion in oncology, 1990, Volume: 2, Issue:6

    Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate

1990

Trials

6 trial(s) available for brequinar and Neoplasms

ArticleYear
Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor.
    Nucleosides, nucleotides & nucleic acids, 2018, Volume: 37, Issue:12

    Topics: Aged; Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Rats; Uridine

2018
Biochemical modulation of 5-fluorouracil with brequinar: results of a phase I study.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine

1995
Protein binding of brequinar in the plasma of healthy donors and cancer patients and analysis of the relationship between protein binding and pharmacokinetics in cancer patients.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Antineoplastic Agents; Biphenyl Compounds; Half-Life; Humans; Injections, Intravenous; Metabolic Clearance Rate; Neoplasms; Protein Binding; Serum Albumin

1994
Pharmacokinetic and phase I studies of brequinar (DUP 785; NSC 368390) in combination with cisplatin in patients with advanced malignancies.
    Investigational new drugs, 1998, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cisplatin; Female; Humans; Male; Middle Aged; Neoplasms; Treatment Outcome

1998
Novel chemotherapeutic agents in early clinical development.
    Current opinion in oncology, 1990, Volume: 2, Issue:6

    Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate

1990
Mucocutaneous side effects of Brequinar sodium. A new inhibitor of pyrimidine de novo biosynthesis.
    Cancer, 1989, Jan-15, Volume: 63, Issue:2

    Topics: Aged; Antineoplastic Agents; Biphenyl Compounds; Diarrhea; Drug Administration Schedule; Drug Eruptions; Drug Evaluation; Female; Humans; Male; Middle Aged; Mucous Membrane; Nausea; Neoplasms; Skin Ulcer; Stomatitis; Vomiting

1989

Other Studies

9 other study(ies) available for brequinar and Neoplasms

ArticleYear
Dihydroorotate Dehydrogenase Inhibitors Promote Cell Cycle Arrest and Disrupt Mitochondria Bioenergetics in Ramos Cells.
    Current pharmaceutical biotechnology, 2020, Volume: 21, Issue:15

    Topics: Biphenyl Compounds; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dicarboxylic Acids; Dihydroorotate Dehydrogenase; Energy Metabolism; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors

2020
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
    Nature, 2021, Volume: 593, Issue:7860

    Topics: Animals; Biphenyl Compounds; Cell Line, Tumor; Dihydroorotate Dehydrogenase; Female; Ferroptosis; Gene Deletion; Humans; Lipid Peroxidation; Metabolomics; Mice, Nude; Mitochondria; Neoplasms; Phospholipid Hydroperoxide Glutathione Peroxidase; Xenograft Model Antitumor Assays

2021
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
    Cancer research, 1990, Aug-01, Volume: 50, Issue:15

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Oxidase; Dose-Response Relationship, Drug; Humans; Lymphocytes; Mice; Mice, Inbred BALB C; Neoplasms; Oxidoreductases; Reference Values; Uridine

1990
Phase I study of Brequinar sodium (NSC 368390) in patients with solid malignancies.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Biphenyl Compounds; Drug Evaluation; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Neoplasms; Platelet Count

1990
Phase I and pharmacokinetic study of brequinar sodium (NSC 368390).
    Cancer research, 1990, Aug-01, Volume: 50, Issue:15

    Topics: Antineoplastic Agents; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Evaluation; Female; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms

1990
A phase I clinical and pharmacokinetic study of Brequinar sodium, DUP 785 (NSC 368390), using a weekly and a biweekly schedule.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biphenyl Compounds; Drug Administration Schedule; Drug Evaluation; Female; Genital Neoplasms, Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Platelet Count; Urologic Neoplasms

1989
Pharmacokinetics of Brequinar sodium (NSC 368390) in patients with solid tumors during a phase I study.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Biphenyl Compounds; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms

1989
Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390).
    Cancer research, 1989, Aug-15, Volume: 49, Issue:16

    Topics: Adult; Aged; Antineoplastic Agents; Biphenyl Compounds; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms

1989
Preclinical phase II studies in human tumor lines: a European multicenter study.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:3

    Topics: Amsacrine; Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Line; Doxorubicin; Drug Evaluation; Europe; Humans; International Cooperation; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms

1988