Compounds > brequinar
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brequinar and Lung Neoplasms

brequinar has been researched along with Lung Neoplasms in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beytagh, MC; Bhutkar, A; Colón, CI; Drapkin, BJ; Dyson, NJ; Farago, AF; Hsu, PP; Jacks, T; Lewis, CA; Li, L; Li, Z; Mercer, KL; Muzumdar, MD; Myers, DT; Nabel, CS; Ng, SR; Phat, S; Romero, R; Vander Heiden, MG; Westcott, PMK1
Dallaire, B; Gyves, J; Maroun, J; Morgan, R; Natale, R; Ruckdeschel, J; Sisk, R1
Cleaveland, ES; Cooney, DA; Ford, H; Kelley, JA; Paull, K; Zaharevitz, DW1
Bork, E; Hansen, HH; Vest, S1
Ardecky, RJ; DeLarco, BM; Dexter, DL; Dusak, BA; Hesson, DP; Narayanan, VL; Paull, KD; Plowman, J; Rao, GV; Tippett, DL1

Trials

1 trial(s) available for brequinar and Lung Neoplasms

ArticleYear
Multicenter phase II study of brequinar sodium in patients with advanced lung cancer.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:1

    Topics: Aged; Antineoplastic Agents; Biphenyl Compounds; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged

1993

Other Studies

4 other study(ies) available for brequinar and Lung Neoplasms

ArticleYear
Identification of DHODH as a therapeutic target in small cell lung cancer.
    Science translational medicine, 2019, 11-06, Volume: 11, Issue:517

    Topics: Adenocarcinoma; Animals; Biphenyl Compounds; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DCMP Deaminase; Dihydroorotate Dehydrogenase; Disease Progression; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Oxidoreductases Acting on CH-CH Group Donors; Pancreatic Neoplasms; Pyrimidines; Small Cell Lung Carcinoma; Survival Analysis; Xenograft Model Antitumor Assays

2019
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
    Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3

    Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lung Neoplasms; Male; Melanoma; Mitochondria; Orotic Acid; Ovarian Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Prostatic Neoplasms; Ribonucleotides; Sodium Bicarbonate; Software; Tumor Cells, Cultured

1996
A phase I clinical and pharmacokinetic study of Brequinar sodium, DUP 785 (NSC 368390), using a weekly and a biweekly schedule.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biphenyl Compounds; Drug Administration Schedule; Drug Evaluation; Female; Genital Neoplasms, Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Platelet Count; Urologic Neoplasms

1989
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 1

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Female; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous

1985