Compounds > brequinar
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brequinar and Colonic Neoplasms

brequinar has been researched along with Colonic Neoplasms in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cleaveland, ES; Cooney, DA; Ford, H; Kelley, JA; Paull, K; Zaharevitz, DW1
Handschumacher, RE; Lentz, SK; Pizzorno, G; Wiegand, RA1
Kraal, I; Peters, GJ; Pinedo, HM1
de Kant, E; Laurensse, EJ; Nadal, JC; Peters, GJ; Pinedo, HM1
de Kant, E; Laurensse, E; Nadal, JC; Peters, GJ; Pinedo, HM1
Ardecky, RJ; DeLarco, BM; Dexter, DL; Dusak, BA; Hesson, DP; Narayanan, VL; Paull, KD; Plowman, J; Rao, GV; Tippett, DL1

Other Studies

6 other study(ies) available for brequinar and Colonic Neoplasms

ArticleYear
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
    Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3

    Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lung Neoplasms; Male; Melanoma; Mitochondria; Orotic Acid; Ovarian Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Prostatic Neoplasms; Ribonucleotides; Sodium Bicarbonate; Software; Tumor Cells, Cultured

1996
Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.
    Cancer research, 1992, Apr-01, Volume: 52, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Colonic Neoplasms; Digestive System; Drug Synergism; Female; Fluorouracil; Kidney; Kinetics; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Spleen; Thymidylate Synthase; Uracil Nucleotides; Uridine

1992
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
    British journal of cancer, 1992, Volume: 65, Issue:2

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine

1992
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
    Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bone Marrow; Colonic Neoplasms; Dihydroorotate Oxidase; Female; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidoreductases; Pyrimidine Nucleotides; Uridine; Uridine Triphosphate

1990
The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Dihydroorotate Oxidase; Dose-Response Relationship, Drug; Humans; Mice; Oxidoreductases; Pyrimidine Nucleotides; Tumor Cells, Cultured

1989
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 1

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Female; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous

1985