brassinin and Breast-Neoplasms

brassinin has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for brassinin and Breast-Neoplasms

Article	Year
Isobrassinin and its analogues: novel types of antiproliferative agents. Bioorganic & medicinal chemistry letters, 2006, Dec-15, Volume: 16, Issue:24 Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30muM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 microM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined. Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; HeLa Cells; Humans; Indoles; Models, Molecular; Structure-Activity Relationship; Thiocarbamates	2006

Article

Year

Isobrassinin and its analogues: novel types of antiproliferative agents.

Bioorganic & medicinal chemistry letters, 2006, Dec-15, Volume: 16, Issue:24

Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30muM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 microM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined.

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; HeLa Cells; Humans; Indoles; Models, Molecular; Structure-Activity Relationship; Thiocarbamates

2006