brain-natriuretic-peptide--porcine and Fever

brain-natriuretic-peptide--porcine has been researched along with Fever* in 2 studies

Other Studies

2 other study(ies) available for brain-natriuretic-peptide--porcine and Fever

ArticleYear
Isatin (Indole-2, 3-dione) inhibits natriuretic peptide-induced hyperthermia in rats.
    Peptides, 2000, Volume: 21, Issue:3

    The effects of an endogenous indole, isatin (indole-2, 3-dione), on the hyperthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 microg caused elevations in colon temperature 30 and 60 min after injection. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possible involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hyperthermic effect in vivo.

    Topics: Analysis of Variance; Animals; Atrial Natriuretic Factor; Body Temperature; Cerebral Ventricles; Fever; Injections, Intraperitoneal; Injections, Intraventricular; Isatin; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Rats; Rats, Wistar

2000
Hyperthermic effect of centrally administered natriuretic peptides in the rat.
    Peptides, 1999, Volume: 20, Issue:2

    The effects of atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32) and C-type natriuretic peptide (CNP-22) on body temperature were investigated in rats. Intracerebroventricular administration of each peptide in doses of 400 or 1000 ng caused a dose-related elevation in colon temperature 30 and 60 min after injection. A 40 ng dose of ANP-28 was also hyperthermic at 60 min. An intramuscular (i.m.) injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the natriuretic peptide-induced hyperthermia. The results show that natriuretic peptides may participate in thermoregulatory processes in the central nervous system, and that their hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.

    Topics: Animals; Atrial Natriuretic Factor; Body Temperature; Colon; Cyclooxygenase Inhibitors; Dipyrone; Dose-Response Relationship, Drug; Fever; Injections, Intraventricular; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Pyrazolones; Rats; Rats, Wistar

1999