bq-123 and Uveitis

To investigate the effect of Bosentan (non-selective endothelin receptor antagonist) and BQ123 (ET. Uveitis was induced by intravitreal injection of lipopolysaccharide (LPS). The animals were divided into 7 groups and there were six rabbits in each group (saline, saline and ethanol, bosentan, BQ123, lipopolysaccharide (LPS), bosentan and LPS, BQ123 and LPS-injected groups). Bosentan and BQ123 were applied before LPS injection. Aqueous humour was collected at 24th hour post-injections and enucleation was performed for the evaluation of histopathological changes.. BQ123 decreased clinical score, cell counts and protein amount more than bosentan and it was significant for cell counts (p = 0.018). Bosentan significantly diminished inflammatory reactions more than BQ123 as shown in histopathological specimens (p = 0.002).. ET

Topics: Animals; Aqueous Humor; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Eye; Eye Proteins; Intravitreal Injections; Leukocyte Count; Lipopolysaccharides; Male; Peptides, Cyclic; Rabbits; Sulfonamides; Uveitis