bpc-157 and Rhinitis

Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.

Topics: Administration, Intranasal; Animals; Capsaicin; Cell Count; Cell Degranulation; Dose-Response Relationship, Drug; Inflammation; Injections, Intraperitoneal; Lymphocytes; Male; Mast Cells; Nasal Mucosa; Nasal Provocation Tests; Neutrophils; Peptide Fragments; Proteins; Rats; Rats, Wistar; Rhinitis; Sodium Chloride