bp-897 has been researched along with Substance-Withdrawal-Syndrome* in 1 studies
1 other study(ies) available for bp-897 and Substance-Withdrawal-Syndrome
| Article | Year |
|---|---|
Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents.
Three series of bitopic benzopyranomorpholine analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined using the method of radioligand binding assay. Most compounds demonstrated considerable binding affinities and selectivity for D3 receptor. Besides, the compounds were screened for their ability to alleviate withdrawal symptoms of opioid addiction in animal behavioral models. The results showed that compound 20h displayed nanomolar affinity for the D3R, and exhibited anti-drug addiction efficacy in the animal model of of naloxone-induced withdrawal symptoms in morphine-dependent mice. Topics: Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Design; Ligands; Mice; Molecular Structure; Morpholines; Naloxone; Receptors, Dopamine D3; Structure-Activity Relationship; Substance Withdrawal Syndrome | 2021 |