bottromycin-a(2) and Gram-Positive-Bacterial-Infections

bottromycin-a(2) has been researched along with Gram-Positive-Bacterial-Infections* in 1 studies

Other Studies

1 other study(ies) available for bottromycin-a(2) and Gram-Positive-Bacterial-Infections

ArticleYear
Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities.
    Bioorganic & medicinal chemistry letters, 2010, Oct-15, Volume: 20, Issue:20

    Novel bottromycin derivatives were synthesized from bottromycin A(2) via a hydrazide derivative as a common intermediate. Seventeen derivatives were subjected to in vitro evaluation against drug-resistant gram-positive bacteria. Some compounds showed potent anti-MRSA and anti-VRE activity, as did bottromycin A(2). Notably, a propyl ketone derivative exhibited good antibacterial activity with excellent metabolite stability.

    Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcaceae; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Peptides, Cyclic; Plasma; Vancomycin

2010