Page last updated: 2024-08-26

bosentan anhydrous and Hypoxia

bosentan anhydrous has been researched along with Hypoxia in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (19.05)	18.2507
2000's	20 (47.62)	29.6817
2010's	12 (28.57)	24.3611
2020's	2 (4.76)	2.80

Authors

Authors	Studies
Baker, SE; Harper, JL; Jacob, DW; Limberg, JK; Manrique-Acevedo, CM; Ott, EP; Scruggs, ZM	1
Sakao, S; Tanabe, N; Tatsumi, K	1
Abman, SH; Kinsella, JP; Mandell, E	1
Chen, LL; Guo, YJ; Ji, ES; Li, WY; Yang, SC; Yu, FY	1
Kim, SH; Lee, GJ; Li, W; Park, BM; Yu, L	1
Lee, JS; Lee, SD; Oh, YM; Park, DA; Park, J; Song, JH	1
Fraidenburg, DR; Guo, Q; Huang, JA	1
Briançon-Marjollet, A; Faure, P; Godin-Ribuot, D; Hazane-Puch, F; Henri, M; Monneret, D; Pepin, JL	1
Belhaj, A; Dewachter, C; Dewachter, L; Maruyama, H; Naeije, R; Remmelink, M; Rondelet, B; Sakai, S; Vachiéry, JL	1
Grassi, G; Janssen, C; Pathak, A; van de Borne, P	1
Broomé, M; Frenckner, B; Lindström, M; Radell, P	1
Agard, C; Haloun, A; Hamidou, MA	1
Boldingh, S; Brimioulle, S; Faoro, V; Huez, S; Lamotte, M; Martinez, S; Moreels, M; Naeije, R; Unger, P	1
Belaidi, E; Godin-Ribuot, D; Joyeux-Faure, M; Launois, SH; Levy, P; Ribuot, C	1
Azizi, M; Peyrard, S; Pham, I; Richalet, JP; Wuerzner, G	1
Choudhary, G; Harrington, EO; Klinger, JR; Martin, D; Troncales, F	1
Burtscher, M; Faulhaber, M; Flatz, M; Kleinsasser, A; Loeckinger, A; Olfert, IM; Treml, B; Truebsbach, S	1
Dinger, B; Fidone, S; He, L; Liu, X; Stensaas, L	1
Bardou, M; Dumas, JP; Dumas, M; Goirand, F; Guerard, P; Rochette, L	1
Abdel Kafi, S; Bejjani, G; Biarent, D; Hubloue, I; Kerbaul, F; Leeman, M; Naeije, R	1
Horowitz, JD; Oliver, JR; Zhang, Y	1
Carpenter, TC; Schomberg, S; Stenmark, KR	1
Bejjani, G; Biarent, D; Hubloue, I; Jespers, P; Leeman, M; Mélot, C; Naeije, R	1
Dauzat, M; Obert, P; Reboul, C; Tanguy, S	1
Del Rio, R; Iturriaga, R; Rey, S	2
Gamberi, T; Gensini, GF; Mancia, G; Marchetta, M; Modesti, A; Modesti, PA; Morabito, M; Parati, G; Savia, G; Sofi, F; Vanni, S	1
Rubin, LJ	1
Argacha, JF; Denewet, N; Gujic, M; Houssière, A; Jespers, P; Melot, C; Naeije, R; Noseda, A; van de Borne, P; Xhaët, O	1
Beuzard, Y; Bonnin, P; Castier, Y; de Franceschi, L; Debbabi, H; Dussaule, JC; Galaup, A; Germain, S; Girot, R; Henri, A; Janin, A; Leboeuf, C; Levy, B; Maier-Redelsperger, M; Malpeli, G; Sabaa, N; Scarpa, A; Tharaux, PL; Vandermeersch, S	1
Brutsche, M; Di Valentino, M; Linka, A; Meyer, A; Rasch, H; Stolz, D; Tamm, M	1
Adnot, S; Clozel, M; Eddahibi, S; Levame, M; Raffestin, B	1
Feihl, F; Kucera, P; Lazor, R; Perret, C; Waeber, B	1
Chen, SJ; Chen, YF; Dicarlo, VS; Durand, J; Meng, QC; Oparil, S	1
Clozel, M; Franco-Cereceda, A; Holm, P; Liska, J	1
Abbott, BM; Bertelsen, DL; DeSiato, MA; Rumsey, WL	1
Albertini, M; Clement, MG	1
Bellissant, E; Durand-Castel, X; Goineau, S; Guillo, P; Pape, D	1
Lombardi, JP; McNamara, JL; Nelson, DP; Pearl, JM; Raake, JL; Wagner, CJ; Wellmann, SA	1
Doi, S; Murray, PA; Smedira, N	1
Chen, YF; Oparil, S	1
Besse, S; Boucher, F; Bulteau, AL; de Leiris, J; Le Page, C; Riou, B; Swynghedauw, B; Tanguy, S	1

Reviews

5 review(s) available for bosentan anhydrous and Hypoxia

Article	Year
Hypoxic Pulmonary Vasoconstriction and the Diffusing Capacity in Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis. Journal of the American Heart Association, 2019, 08-20, Volume: 8, Issue:16 Topics: Bosentan; Disease Progression; Endothelin Receptor Antagonists; Enzyme Activators; Humans; Hypertension, Pulmonary; Hypoxia; Idiopathic Pulmonary Fibrosis; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Circulation; Pulmonary Diffusing Capacity; Pulmonary Ventilation; Pyrazoles; Pyrimidines; Sildenafil Citrate; Treatment Failure; Vascular Remodeling; Vasoconstriction	2019
Persistent pulmonary hypertension of the newborn. Pediatric pulmonology, 2021, Volume: 56, Issue:3 Topics: Bosentan; Epoprostenol; Humans; Hypertension, Pulmonary; Hypoxia; Infant; Infant, Newborn; Infant, Premature; Lung; Milrinone; Nitric Oxide; Oxygen; Persistent Fetal Circulation Syndrome; Pulmonary Alveoli; Pulmonary Surfactants; Risk; Sildenafil Citrate; Vascular Resistance; Vasodilator Agents	2021
Systematic review and meta-analysis of pulmonary hypertension specific therapy for exercise capacity in chronic obstructive pulmonary disease. Journal of Korean medical science, 2013, Volume: 28, Issue:8 Topics: Antihypertensive Agents; Bosentan; Clinical Trials as Topic; Databases, Factual; Epoprostenol; Humans; Hypertension, Pulmonary; Hypoxia; Piperazines; Pulmonary Disease, Chronic Obstructive; Purines; Risk Factors; Sildenafil Citrate; Sulfonamides; Sulfones; Surveys and Questionnaires	2013
[Pulmonary arterial hypertension related to systemic sclerosis in 2008]. Journal des maladies vasculaires, 2009, Volume: 34, Issue:1 Topics: Altitude; Antihypertensive Agents; Bosentan; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; France; Humans; Hypertension, Pulmonary; Hypoxia; Oxygen; Phosphodiesterase 5 Inhibitors; Prognosis; Scleroderma, Systemic; Sulfonamides	2009
Endothelial dysfunction in the pulmonary vascular bed. The American journal of the medical sciences, 2000, Volume: 320, Issue:4 Topics: Animals; Antihypertensive Agents; Atrasentan; Bosentan; Controlled Clinical Trials as Topic; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Hypoxia; Lung Diseases, Obstructive; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Circulation; Pyrrolidines; Receptors, Endothelin; RNA, Messenger; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation	2000

Trials

7 trial(s) available for bosentan anhydrous and Hypoxia

Article	Year
Endothelin contributes to the blood pressure rise triggered by hypoxia in severe obstructive sleep apnea. Journal of hypertension, 2017, Volume: 35, Issue:1 Topics: Adrenergic Fibers; Adult; Blood Pressure; Bosentan; Chemoreceptor Cells; Cross-Over Studies; Double-Blind Method; Endothelin Receptor Antagonists; Endothelins; Humans; Hypoxia; Male; Middle Aged; Oxygen; Pulmonary Ventilation; Severity of Illness Index; Sleep Apnea, Obstructive; Sulfonamides; Sympathetic Nervous System	2017
Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. Chest, 2009, Volume: 135, Issue:5 Topics: Adult; Antihypertensive Agents; Bosentan; Cardiac Output; Cross-Over Studies; Double-Blind Method; Exercise Tolerance; Female; Hemodynamics; Humans; Hypoxia; Male; Middle Aged; Oxygen Consumption; Sulfonamides; Vascular Resistance; Young Adult	2009
Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans. European journal of clinical investigation, 2010, Volume: 40, Issue:3 Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Gas Analysis; Blood Pressure; Bosentan; Cardiac Output; Cross-Over Studies; Double-Blind Method; Echocardiography; Endothelin Receptor Antagonists; Exercise; Humans; Hypoxia; Male; Middle Aged; Oxygen; Pulmonary Artery; Pulmonary Circulation; Sulfonamides	2010
Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial. Wilderness & environmental medicine, 2011, Volume: 22, Issue:3 Topics: Adult; Altitude; Bosentan; Cardiac Output; Exercise; Female; Humans; Hypoxia; Male; Mountaineering; Oxygen; Piperazines; Pulmonary Gas Exchange; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Treatment Outcome; Vasodilator Agents	2011
Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation, 2006, Sep-26, Volume: 114, Issue:13 Topics: Acute Disease; Adaptation, Physiological; Adult; Altitude; Altitude Sickness; Arginine Vasopressin; Bosentan; Creatinine; Diuresis; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Female; Glomerular Filtration Rate; Humans; Hypertension, Pulmonary; Hypoxia; Kidney; Kidney Diseases; Male; Middle Aged; Muscle, Smooth, Vascular; Osmolar Concentration; Oxygen; Potassium Channels, Voltage-Gated; Pulmonary Artery; Pulmonary Edema; Receptors, Endothelin; Sulfonamides; Vasoconstriction	2006
Does endothelin play a role in chemoreception during acute hypoxia in normal men? Chest, 2007, Volume: 131, Issue:5 Topics: Acute Disease; Adult; Apnea; Blood Pressure; Bosentan; Chemoreceptor Cells; Cross-Over Studies; Double-Blind Method; Endothelin Receptor Antagonists; Endothelins; Heart Rate; Humans; Hypoxia; Male; Muscles; Pulmonary Ventilation; Receptors, Endothelin; Sulfonamides; Sympathetic Nervous System	2007
A randomised, controlled trial of bosentan in severe COPD. The European respiratory journal, 2008, Volume: 32, Issue:3 Topics: Aged; Bosentan; Double-Blind Method; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Sulfonamides; Vasodilator Agents	2008

Other Studies

30 other study(ies) available for bosentan anhydrous and Hypoxia

Article	Year
Endothelin-1 receptor blockade does not alter the sympathetic and hemodynamic response to acute intermittent hypoxia in men. Journal of applied physiology (Bethesda, Md. : 1985), 2022, 10-01, Volume: 133, Issue:4 Topics: Baroreflex; Blood Pressure; Bosentan; Endothelin-1; Endothelins; Heart Rate; Hemodynamics; Humans; Hypoxia; Male; Muscle, Skeletal; Oxygen; Receptor, Endothelin A; Sympathetic Nervous System	2022
[Bosentan ameliorates hypertension in rats exposed to chronic intermittent hypoxia through inhibiting renal sympathetic nerve activity]. Sheng li xue bao : [Acta physiologica Sinica], 2018, Aug-25, Volume: 70, Issue:4 Topics: Animals; Baroreflex; Blood Pressure; Bosentan; Endothelin-1; Hypertension; Hypoxia; Kidney; Male; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System	2018
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway. Peptides, 2019, Volume: 121 Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulation; Glyburide; Heart Atria; Hydrogen Sulfide; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; KATP Channels; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Organ Culture Techniques; Oxygen; Pinacidil; Potassium Channel Blockers; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides	2019
Bosentan as rescue treatment in refractory hypoxemia and pulmonary hypertension in a patient with ARDS and H7N9 influenza virus infection. Lung, 2014, Volume: 192, Issue:5 Topics: Antihypertensive Agents; Antiviral Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Hypoxia; Influenza A Virus, H7N9 Subtype; Influenza, Human; Male; Middle Aged; Positive-Pressure Respiration; Respiratory Distress Syndrome; Sulfonamides; Treatment Outcome	2014
Endothelin regulates intermittent hypoxia-induced lipolytic remodelling of adipose tissue and phosphorylation of hormone-sensitive lipase. The Journal of physiology, 2016, Mar-15, Volume: 594, Issue:6 Topics: 3T3 Cells; Adipose Tissue; Animals; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Fatty Acids; Hypoxia; Lipolysis; Male; Mice; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Wistar; Receptors, Endothelin; Sterol Esterase; Sulfonamides; Triglycerides	2016
Bosentan reverses the hypoxia-induced downregulation of the bone morphogenetic protein signaling in pulmonary artery smooth muscle cells. Life sciences, 2016, Aug-15, Volume: 159 Topics: Bone Morphogenetic Proteins; Bosentan; Cells, Cultured; Cobalt; Down-Regulation; Endothelin Receptor Antagonists; Humans; Hypoxia; Muscle, Smooth, Vascular; Pulmonary Artery; Signal Transduction; Sulfonamides	2016
Platelet-derived growth factor inhibition--a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? Journal of pediatric surgery, 2008, Volume: 43, Issue:10 Topics: Benzamides; Bosentan; Combined Modality Therapy; Continuous Positive Airway Pressure; Diuretics; Enteral Nutrition; Extracorporeal Membrane Oxygenation; Heart Failure; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Hypertension, Pulmonary; Hypoxia; Iloprost; Imatinib Mesylate; Infant, Newborn; Male; Nitric Oxide; Piperazines; Protein Kinase Inhibitors; Purines; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Sildenafil Citrate; Sulfonamides; Sulfones	2008
Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Journal of the American College of Cardiology, 2009, Apr-14, Volume: 53, Issue:15 Topics: Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Disease Models, Animal; Endothelin-1; Genetic Predisposition to Disease; Heart; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1; Male; Myocardial Infarction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sleep Apnea, Obstructive; Sulfonamides	2009
Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2011, Volume: 30, Issue:7 Topics: Animals; Antihypertensive Agents; Bosentan; Collagen; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Myocardium; Protein Isoforms; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Ventricular Dysfunction, Right	2011
Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body. High altitude medicine & biology, 2012, Volume: 13, Issue:3 Topics: Acid Sensing Ion Channels; Adaptation, Physiological; Animals; Antihypertensive Agents; Bosentan; Carotid Body; Cell Movement; Chemokine CCL2; Chemoreceptor Cells; Chronic Disease; Endothelin-1; Gene Expression; Hypoxia; Inflammation; Interleukin-1; Interleukin-1beta; Leukocyte Common Antigens; Macrophages; Rats; Receptor, Endothelin A; Sulfonamides; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase	2012
ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:1 Topics: Animals; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Hypoxia; Indoles; Lung; Male; Maleimides; Nitric Oxide Synthase; Oligopeptides; Peptides, Cyclic; Piperidines; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides; Vasoconstriction	2003
Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction. The European respiratory journal, 2003, Volume: 21, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Dogs; Endothelin Receptor Antagonists; Endothelins; Hypoxia; Lung; Nitric Oxide; Nitroarginine; Sulfonamides; Vascular Resistance; Vasoconstriction	2003
The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release. Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:2 Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Bosentan; Endothelin Receptor Antagonists; Endothelins; Heart; Hypoxia; Male; Myocardial Ischemia; Peptides, Cyclic; Radioimmunoassay; Rats; Sulfonamides	2004
Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 289, Issue:6 Topics: Animals; Antihypertensive Agents; Bosentan; Capillary Permeability; Endothelin Receptor Antagonists; Endothelins; Hypoxia; Male; Pulmonary Alveoli; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Respirovirus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sendai virus; Serum Albumin; Sulfonamides; Vascular Endothelial Growth Factor A	2005
Role of endothelins and nitric oxide in the pulmonary circulation of perinatal lambs during hyperoxia and hypoxia. Pediatric research, 2006, Volume: 59, Issue:1 Topics: Animals; Animals, Newborn; Blood Pressure; Bosentan; Constriction, Pathologic; Dilatation, Pathologic; Endothelin Receptor Antagonists; Endothelins; Hyperoxia; Hypoxia; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pulmonary Artery; Pulmonary Circulation; Sheep, Domestic; Sulfonamides; Vascular Resistance	2006
Chronic exercise does not prevent hypoxia-induced increased aortic sensitivity to endothelin in rats. Vascular pharmacology, 2006, Volume: 44, Issue:5 Topics: Animals; Aorta, Thoracic; Bosentan; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hypoxia; Male; Physical Conditioning, Animal; Potassium Chloride; Rats; Receptor, Endothelin A; Sulfonamides; Vasoconstriction; Vasoconstrictor Agents	2006
Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. Brain research, 2006, May-01, Volume: 1086, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Carotid Body; Cats; Chemoreceptor Cells; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Gene Expression; Hypoxia; Immunohistochemistry; Male; Oxygen; Sulfonamides	2006
Role of endothelin-1 on the enhanced carotid body activity induced by chronic intermittent hypoxia. Advances in experimental medicine and biology, 2006, Volume: 580 Topics: Animals; Bosentan; Carotid Body; Cats; Chronic Disease; Electrophysiology; Endothelin Receptor Antagonists; Endothelin-1; Hypoxia; Immunohistochemistry; In Vitro Techniques; Male; Sulfonamides	2006
Endothelin-1 and the pulmonary vascular response to altitude: a new therapeutic target? Circulation, 2006, Sep-26, Volume: 114, Issue:13 Topics: Altitude; Altitude Sickness; Bosentan; Diuresis; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia; Kidney Diseases; Muscle, Smooth, Vascular; Potassium Channels, Voltage-Gated; Randomized Controlled Trials as Topic; Receptors, Endothelin; Sulfonamides; Vasoconstriction; Ventricular Function, Right	2006
Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. The Journal of clinical investigation, 2008, Volume: 118, Issue:5 Topics: Anemia, Sickle Cell; Animals; Antihypertensive Agents; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Humans; Hypoxia; Kidney; Lung; Mice; Mice, Inbred C57BL; Neutrophils; Receptors, Endothelin; Regional Blood Flow; Renal Circulation; Sulfonamides; Vasoconstriction	2008
Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2 Topics: Animals; Bosentan; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Male; Rats; Rats, Wistar; Sulfonamides	1995
Endothelin-1 does not mediate the endothelium-dependent hypoxic contractions of small pulmonary arteries in rats. Chest, 1996, Volume: 110, Issue:1 Topics: Animals; Bosentan; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstriction	1996
Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:6 Topics: Animals; Blood Pressure; Bosentan; Heart Rate; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors	1995
The endothelin antagonist bosentan: hemodynamic effects during normoxia and hypoxic pulmonary hypertension in pigs. The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bosentan; Cardiac Output; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Oxygen; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Sulfonamides; Swine; Thromboxane A2; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Viper Venoms	1996
Nitric oxide and endothelin in acute hypoxic pulmonary vasoconstriction and adaptation to chronic hypoxia. Advances in experimental medicine and biology, 1997, Volume: 428 Topics: Acclimatization; Acute Disease; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Chronic Disease; Endothelium, Vascular; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstriction	1997
Hypoxic pulmonary vasoconstriction in pigs: role of endothelin-1, prostanoids and ATP-dependent potassium channels. Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 59, Issue:2 Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Cardiac Output; Cromakalim; Cyclooxygenase Inhibitors; Endothelin-1; Female; Heart Rate; Hypoxia; Indomethacin; Male; Potassium Channels; Pulmonary Artery; Pulmonary Ventilation; Sulfonamides; Swine; Vascular Resistance; Vasoconstriction	1998
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat. Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides	1999
Bosentan prevents hypoxia-reoxygenation-induced pulmonary hypertension and improves pulmonary function. The Annals of thoracic surgery, 1999, Volume: 68, Issue:5 Topics: Animals; Animals, Newborn; Antihypertensive Agents; Bosentan; Cardiopulmonary Bypass; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Nitric Oxide; Oxygen; Pulmonary Artery; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Swine; Vascular Resistance	1999
Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation. Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 88, Issue:1 Topics: Animals; Azepines; Bosentan; Carbon Dioxide; Consciousness; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Hydrogen-Ion Concentration; Hypoxia; Lung; Lung Transplantation; Male; Oligopeptides; Oxygen; Pulmonary Artery; Pulmonary Circulation; Receptors, Endothelin; Respiration; Sulfonamides; Vascular Resistance; Vasoconstriction	2000
Coronary and aortic vasoreactivity protection with endothelin receptor antagonist, bosentan, after ischemia and hypoxia in aged rats. European journal of pharmacology, 2001, Dec-07, Volume: 432, Issue:2-3 Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Bosentan; Coronary Circulation; Coronary Vessels; Endothelin Receptor Antagonists; Hypoxia; In Vitro Techniques; Male; Myocardial Ischemia; Nitroprusside; Oxygen; Phenylephrine; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2001