bortezomib has been researched along with Lymphoma--B-Cell* in 1 studies
1 other study(ies) available for bortezomib and Lymphoma--B-Cell
| Article | Year |
|---|---|
Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines.
Cancer cells isolated from two patients with malignant non-Hodgkin B-cell lymphomas that became resistant to chemotherapy during clinical treatment were made ≥fourfold resistant in culture to anticancer drugs, that is cisplatin, etoposide, methotrexate and bortezomib. Because most resistant lines showed significantly increased expression of the anti-oxidative enzyme glutathione peroxidase 1 (GPx1), GPx1 was investigated as a target for inhibitor development. Virtual screening of a library of diverse structures by docking them to the active site of the X-ray crystal structure of bovine GPx1 uncovered compounds that might block the enzyme. An enzyme assay confirmed an acylhydrazone heterocycle (3) with GPx inhibitory activity. Combinations of 3 with the anticancer drugs listed above led to reversal of resistance in the lymphoma cell lines. Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catalytic Domain; Cattle; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glutathione Peroxidase; Humans; Hydrazones; Inhibitory Concentration 50; Lymphoma, B-Cell; Molecular Structure | 2012 |