boron and Urinary-Calculi

Treatment with alpha-blockers has been used in many studies to facilitate stone clearance after extra-corporeal shock wave lithotripsy (ESWL), based on mediating ureteral wall relaxation. Ureteral wall edema is another barrier against the stone passage. We aimed to compare the effectiveness of boron supplement (due to its anti-inflammatory effect) and tamsulosin in the passage of stone fragments after ESWL. Eligible patients after ESWL were randomly assigned to two groups and were treated with boron supplement (10 mg/BD) or tamsulosin (0.4 mg per night) for 2 weeks. The primary outcome was the stone expulsion rate according to the remained fragmented stone burden. The secondary outcomes were the time of stone clearance, pain intensity, drug side effects, and the need for auxiliary procedures. In this randomized control trial, 200 eligible patients were treated with boron supplement or tamsulosin. Finally, 89 and 81 patients in the two groups completed the study, respectively. The expulsion rate was 46.6% in the boron and 38.7% in the tamsulosin group, which there was no statistically significant difference between the two groups (p = 0.003), as well as the time of stone clearance (7.47 ± 22.4 vs 6.52 ± 18.45, days, p = 0.648, respectively), after 2-week follow-up. Moreover, pain intensity was the same in both groups. No Significant side effects were reported in the two groups. Boron supplement could be effective as adjuvant medical expulsive therapy after ESWL with no significant side effects in short-term follow-up. Iranian Clinical Trial Registration number and date of registration: IRCT20191026045244N3, 07/29/2020.

Topics: Boron; Humans; Iran; Lithotripsy; Sulfonamides; Tamsulosin; Treatment Outcome; Ureteral Calculi; Urinary Calculi

Stone disease is an increasingly common form of renal disease. Therapy to prevent stones rests in lowering supersaturation uses both diet and medication. Environmental factors, especially diet, play an important role in the expression of the tendency to stone formation. Effective treatment decreases stone recurrence and need to use procedures to stone removal. Considering the nutrients, boron as an ultratrace element of the plant food is assumed to have an impact on the stone removal.. Female patient with a 10.0 mm stone in the lower pole underwent an extracorporeal shock wave lithotripsy (ESWL) and received 10 mg of boron supplement/day for two weeks.. Ultrasonography assessment revealed complete stone removal or disposal without hydronephrosis with a significant pain alleviation and significant reduction in ureter bleeding or hematuria along with a little burning sensation in the genital region. The expulsion was confirmed by the collection of the lithiasic residues.. Successful and comfortable kidney stone repulsion with a minor pain and bleeding indicates that the impact of boron in this issue deserves further study and clarification.

Topics: Acute Pain; Aged; Boron; Combined Modality Therapy; Female; Hematuria; Humans; Lithotripsy; Trace Elements; Treatment Outcome; Urinary Calculi