boron and Kidney-Calculi

Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation.. Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75% ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the first day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group).. Kidney sections showed that crystals in the EG group increased significantly in comparison with the control group. Crystal calcium deposition score in groups of EG+B (160), EG+Vit E, and EG+B+Vit E showed a significant decrease compared to EG group. Measurement of the renal tubules area and renal tubular epithelial histological score showed the highest significant dilation in the EG group. Tubular dilation in the EG+B+Vit E group decreased compared to the EG+B and EG+Vit E groups.. Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.

Topics: Animals; Antioxidants; Boron; Calcium; Ethylene Glycol; Kidney; Kidney Calculi; Kidney Tubules; Male; Oxidative Stress; Rats; Rats, Wistar; Trace Elements; Vitamin E

Stone disease is an increasingly common form of renal disease. Diet plays an important role in expression of the tendency to stone formation. Renal epithelial cell injury by reactive oxygen species is a pre-requisite step and the administration of natural antioxidants has been used to protect against nephrolithiasis. Considering the nutrients, boron as an ultra-trace element is revealing to enhance the antioxidant defense mechanism and along vitamin status seems to have an impact on the stone removal.. A male patient with urolithiasis received daily boron plus antioxidants supplement and asked to consume enough of the dairy serving products plus adequate liquids.. Ultrasonography assessment revealed continuous stone removal or disposal without hydronephrosis with significant pain alleviation and reduction in hematuria. The lithiasic residues were collected. The 9*20 mm size of the one eliminated stone is of noteworthy.. Successful and comfortable kidney stone repulsion with a minor pain and bleeding indicates that this impact of boron plus antioxidants deserves further study and clarification.

Topics: Antioxidants; Boron; Dietary Supplements; Drug Therapy, Combination; Humans; Kidney Calculi; Male; Middle Aged; Pain