boron and Helicobacter-Infections

Helicobacter pylori infection is implicated in the aetiology of many diseases. Despite numerous studies, a painless, fast and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymatic environment of the gastric mucosa. Herein, we report the use of stable magnetic graphitic nanocapsules (MGNs), for in situ targeted magnetic resonance imaging (MRI) detection of H. pylori. Several layers of graphene as the shell effectively protect the magnetic core from corrosion while retaining the superior contrast effect for MRI in the gastric environment. Boronic-polyethylene glycol molecules were synthesized and modified on the MGN surface for targeted MRI detection. In a mouse model of H. pylori-induced infection, H. pylori was specifically detected through both T

Topics: Animals; Boron; Cell Line, Tumor; Contrast Media; Gastric Acid; Gastric Mucosa; Graphite; Helicobacter Infections; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Magnetics; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nanocapsules; Polyethylene Glycols; Spectrum Analysis, Raman; Urease