boron and Edema

boron has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for boron and Edema

Article	Year
Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7 PDE4 inhibitors are a validated approach as anti-inflammatory agents but are limited by systemic side effects including emesis. We report a soft-drug strategy incorporating a carboxylic ester group into boron-containing PDE4 inhibitors leading to the discovery of a series of benzoxaborole compounds with good potency (for example IC(50)=47 nM of compound 2) and low emetic activity. These compounds are intended for dermatological use further limiting possible systemic side effects. Topics: Animals; Anti-Inflammatory Agents; Boron; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear; Edema; Humans; Mice; Phosphodiesterase 4 Inhibitors	2010

Article

Year

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.

Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7

PDE4 inhibitors are a validated approach as anti-inflammatory agents but are limited by systemic side effects including emesis. We report a soft-drug strategy incorporating a carboxylic ester group into boron-containing PDE4 inhibitors leading to the discovery of a series of benzoxaborole compounds with good potency (for example IC(50)=47 nM of compound 2) and low emetic activity. These compounds are intended for dermatological use further limiting possible systemic side effects.

Topics: Animals; Anti-Inflammatory Agents; Boron; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear; Edema; Humans; Mice; Phosphodiesterase 4 Inhibitors

2010