boron and Birth-Weight

This study was conducted to assess the blood boron levels (BBL) in prepubertal children in the West and Central Anatolia regions of Turkey and its relationship with chosen anthropometric measurements. A multistage sampling design that combined multicluster (West Anatolia vs. Central Anatolia regions and rural vs. urban residents) and simple random sampling methods were used for the sample selection. BBL was measured using inductively coupled plasma mass spectrometry. Weight, height, mid-arm circumference, and triceps skinfold thickness were measured. Z-scores for weight-for-age, height-for-age, and body mass index (BMI)-for-age were calculated. Furthermore, arm-muscle area, arm-fat area, and fat percentage were measured. This study enrolled 2126 children, of whom 50.7% were male. The mean age was 8.9 years. The mean concentration of BBL was 15.6 μg/L (interquartile range: 11.7-19.6 μg/L). Children in urban areas had significantly higher BBL than those in rural areas (17.2 ± 5.5 vs. 11.9 ± 4.6 μg/L; p < .001). Children in the West Anatolia region had significantly lower BBL than those in the Central Anatolia region (14.5 ± 5.9 μg/L vs. 17.8 ± 5.0 μg/L; p < .001). BBL was not affected by maternal education, occupation, sex, and anemia. BBL was found to be significantly lower in children with low BMI, low triceps skinfold thickness, low arm fat area, and low-fat percentage. Change in BBL was associated with the region and residence in Turkey. BBL differed between well-nourished and malnourished children. Further studies are needed to evaluate the relationship between anthropometry and BBL.

Topics: Birth Weight; Body Height; Body Mass Index; Body Weight; Boron; Child; Female; Humans; Infant, Newborn; Male; Malnutrition; Muscle, Skeletal; Puberty; Rural Population; Tobacco Smoke Pollution; Turkey; Urban Population

Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By contrast, studies on boron-mediated developmental effects in females are scarce. The present study was designed to fill this gap. Hundred and ninety nine females residing in Bandirma and Bigadic participated in this study investigating pregnancy outcomes. The participants constituted a study group covering blood boron from low (< 100 ng B/g blood, n = 143) to high (> 150 ng B/g blood, n = 27) concentrations. The mean blood boron concentration and the mean estimated daily boron exposure of the high exposure group was 274.58 (151.81-975.66) ng B/g blood and 24.67 (10.47-57.86) mg B/day, respectively. In spite of the high level of daily boron exposure, boron-mediated adverse effects on induced abortion, spontaneous abortion (miscarriage), stillbirth, infant death, neonatal death, early neonatal death, preterm birth, congenital anomalies, sex ratio and birth weight of newborns were not observed.

Topics: Birth Weight; Boron; Female; Food Contamination; Humans; Infant, Newborn; Linear Models; Maternal Exposure; Pregnancy; Pregnancy Outcome; Turkey; Water Pollutants, Chemical

Boron is a metalloid found at highly varying concentrations in soil and water. Experimental data indicate that boron is a developmental toxicant, but the few human toxicity data available concern mostly male reproduction.. To evaluate potential effects of boron exposure through drinking water on pregnancy outcomes.. In a mother-child cohort in northern Argentina (n=194), 1-3 samples of serum, whole blood and urine were collected per woman during pregnancy and analyzed for boron and other elements to which exposure occurred, using inductively coupled plasma mass spectrometry. Infant weight, length and head circumference were measured at birth.. Drinking water boron ranged 377-10,929μg/L. The serum boron concentrations during pregnancy ranged 0.73-605μg/L (median 133μg/L) and correlated strongly with whole-blood and urinary boron, and, to a lesser extent, with water boron. In multivariable-adjusted linear spline regression analysis (non-linear association), we found that serum boron concentrations above 80μg/L were inversely associated with birth length (B-0.69cm, 95% CI -1.4; -0.024, p=0.043, per 100μg/L increase in serum boron). The impact of boron appeared stronger when we restricted the exposure to the third trimester, when the serum boron concentrations were the highest (0.73-447μg/L). An increase in serum boron of 100μg/L in the third trimester corresponded to 0.9cm shorter and 120g lighter newborns (p=0.001 and 0.021, respectively).. Considering that elevated boron concentrations in drinking water are common in many areas of the world, although more screening is warranted, our novel findings warrant additional research on early-life exposure in other populations.

Topics: Adolescent; Adult; Argentina; Birth Weight; Boron; Cohort Studies; Drinking Water; Female; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Outcome; Young Adult