boron-10-atom and Neoplasms

Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Humans; Isotopes; Melanoma; Neoplasms; Phenylalanine; Positron-Emission Tomography

Boron neutron capture therapy (BNCT), advanced cancer treatment utilizing nuclear fission of

Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Glycerol; Mice; Nanodiamonds; Neoplasms

Boron neutron capture therapy (BNCT) for cancer is on the rise worldwide due to recent developments of in-hospital neutron accelerators which are expected to revolutionize patient treatments. There is an urgent need for improved boron delivery agents, and herein we have focused on studying the biochemical foundations upon which a successful GLUT1-targeting strategy to BNCT could be based. By combining synthesis and molecular modeling with affinity and cytotoxicity studies, we unravel the mechanisms behind the considerable potential of appropriately designed glucoconjugates as boron delivery agents for BNCT. In addition to addressing the biochemical premises of the approach in detail, we report on a hit glucoconjugate which displays good cytocompatibility, aqueous solubility, high transporter affinity, and, crucially, an exceptional boron delivery capacity in the

Topics: Boron; Boron Neutron Capture Therapy; Cell Line, Tumor; Drug Carriers; Drug Liberation; Glucose; Glucose Transporter Type 1; Humans; Isotopes; Molecular Docking Simulation; Neoplasms

Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Drug Carriers; Female; Humans; Integrin alphaVbeta3; Intravital Microscopy; Isotopes; Mice; Neoplasms; Peptides, Cyclic; Serum Albumin, Bovine; Xenograft Model Antitumor Assays

The shortcomings in Boron neutron capture therapy (BNCT) and Hyperthermia for killing the tumor cell desired for the synthesis of a new kind of material suitable to be first used in BNCT and later on enable the conditions for Hyperthermia to destroy the tumor cell. The desire led to the synthesis of large band gap semiconductor nano-size Boron-10 enriched crystals of hexagonal boron nitride (

Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Hyperthermia, Induced; Isotopes; Microscopy, Electron, Transmission; Nanoparticles; Nanotechnology; Neoplasms; Photoelectron Spectroscopy; Quantum Dots; Spectrum Analysis, Raman; X-Ray Diffraction

This paper presents Neutron Capture Enhanced Particle Therapy (NCEPT), a method for enhancing the radiation dose delivered to a tumour relative to surrounding healthy tissues during proton and carbon ion therapy by capturing thermal neutrons produced inside the treatment volume during irradiation. NCEPT utilises extant and in-development boron-10 and gadolinium-157-based drugs from the related field of neutron capture therapy. Using Monte Carlo simulations, we demonstrate that a typical proton or carbon ion therapy treatment plan generates an approximately uniform thermal neutron field within the target volume, centred around the beam path. The tissue concentrations of neutron capture agents required to obtain an arbitrary 10% increase in biological effective dose are estimated for realistic treatment plans, and compared to concentrations previously reported in the literature. We conclude that the proposed method is theoretically feasible, and can provide a worthwhile improvement in the dose delivered to the tumour relative to healthy tissue with readily achievable concentrations of neutron capture enhancement drugs.

Topics: Boron; Boron Neutron Capture Therapy; Computer Simulation; Dose-Response Relationship, Radiation; Feasibility Studies; Gadolinium; Heavy Ion Radiotherapy; Humans; Isotopes; Models, Biological; Monte Carlo Method; Neoplasms; Neutrons; Phantoms, Imaging; Protons; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted

The next step in the boron neutron capture therapy (BNCT) is the real time imaging of the boron concentration in healthy and tumor tissue. Monte Carlo simulations are employed to predict the detector response required to realize single-photon emission computed tomography in BNCT, but have failed to correctly resemble measured data for cadmium telluride detectors. In this study we have tested the gamma production cross-section data tables of commonly used libraries in the Monte Carlo code MCNP in comparison to measurements. The cross section data table TENDL-2008-ACE is reproducing measured data best, whilst the commonly used ENDL92 and other studied libraries do not include correct tables for the gamma production from the cadmium neutron capture reaction that is occurring inside the detector. Furthermore, we have discussed the size of the annihilation peaks of spectra obtained by cadmium telluride and germanium detectors.

Topics: Boron; Boron Neutron Capture Therapy; Cadmium Compounds; Computer Simulation; Humans; Isotopes; Monte Carlo Method; Neoplasms; Phantoms, Imaging; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Spectrometry, Gamma; Tellurium; Tomography, Emission-Computed, Single-Photon