boldenone-undecylenate and Body-Weight

This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4.4 mg/kg body weight (bwt) BOL 5% oily solution. Group C rabbits received 8.8 mg/kg bwt BOL. Rabbits were injected intramuscularly twice weekly for two months. BOL had no significant effect on the bwt and bwt gain. Testes and epididymis weights were decreased significantly in the BOL-treated groups. BOL caused significant reduction in serum testosterone level, seminal volume, sperm motility, and sperm count. No abnormalities were detected in the sperm morphology of the BOL-treated groups. Histopathological alterations in the testes and epididymis were marked in the group C rabbits. These results indicate that administration of BOL exerts a significant harmful effect on the reproductive functions of male rabbits.

Topics: Anabolic Agents; Animals; Body Weight; Epididymis; Male; Rabbits; Reproduction; Sperm Count; Sperm Motility; Spermatozoa; Testis; Testosterone

Anabolic androgenic steroid (AAS) abuse by adolescents represents a significant health care risk due to the potential for long-term negative physical and psychological sequelae, including increased aggressive behavior. The current experiments examined the effects of AAS use in young male adolescent hamsters (Mesocricetus auratus) and their consequences on aggressive behavior. It was hypothesized that AAS administration during adolescence predisposes hamsters to heightened levels of aggressive behavior (i.e., offensive aggression). To test this hypothesis adolescent male hamsters were administered high doses of synthetic AAS to mimic a 'heavy use' self-administration regimen used by athletes. Immediately following the exposure to AAS hamsters were tested for aggressive behavior using a resident-intruder model. Animals treated with high doses of AAS during their adolescent development showed heightened measures of offensive aggression i.e., decreased latency to bite and increased total number of attacks and bites) during the test period, while measures of total activity (total contact time) between the animals remained unchanged. AAS-treated males did not differ in body weight from controls, suggesting that the increased aggression was not due to increased body mass. The results of this study show that exposure to AAS during adolescence facilitates aggressive response patterns, but does not alter body weight.

Topics: Aggression; Anabolic Agents; Animals; Body Weight; Cricetinae; Male; Mesocricetus; Nandrolone; Testosterone

Mature female rats given food and water ad libitum and maintained under a lighting schedule of 12h light/12h dark were treated with boldenone undecylenate. Neither dosage nor duration of treatment had a significant effect on weight gain when compared to controls. All treated females were characterized by the absence of cyclic ovarian activity that continued for several weeks following termination of treatment. Long term reproductive performance was altered by a significant reduction in both conception rate and neonatal survival. Behavioral patterns were modified for several months following steroid withdrawal.

Topics: Aggression; Animals; Body Weight; Cannibalism; Female; Fertility; Litter Size; Organ Size; Ovary; Pregnancy; Rats; Reproduction; Testosterone

Four groups of dogs made acutely uremic were treated with placebo, 0.5 mg/kg, 1.0 mg/kg, and 1.5 mg/kg of an anabolic steroid (3-oxo-delta 1,4 androstadiene-17 beta-ol-undecylenate). Pretreatment and posttreatment measurements of food intake, body weight, PCV, serum creatinine concentration, plasma albumin concentration, nitrogen balance, lean body mass, and limb circumference did not indicate any beneficial effect of this drug in this model of acute uremia.

Topics: Animals; Body Weight; Creatinine; Disease Models, Animal; Dog Diseases; Dogs; Eating; Female; Hematocrit; Male; Placebos; Serum Albumin; Testosterone; Uremia