bohemine and Neoplasms
bohemine has been researched along with Neoplasms in 2 studies
bohemine : Purine substituted on C-2, C-6 and N-9 with (3-hydroxypropyl)amino, benzylamino and isopropyl groups respectively; a synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor that is structurally similar to olomoucine and roscovitine.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Determination of pharmacokinetic properties in the intact animal remains a major bottleneck in drug discovery." | 1.32 | Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. ( Fischer, PM; Goddard, PM; Lane, DP; Nutley, BP; Raynaud, FI; Workman, P, 2004) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Raynaud, FI | 1 |
| Fischer, PM | 1 |
| Nutley, BP | 1 |
| Goddard, PM | 1 |
| Lane, DP | 1 |
| Workman, P | 1 |
| Skalnikova, H | 1 |
| Halada, P | 1 |
| Dzubak, P | 1 |
| Hajduch, M | 1 |
| Kovarova, H | 1 |
Other Studies
2 other studies available for bohemine and Neoplasms
| Article | Year |
|---|---|
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.
Topics: Animals; Area Under Curve; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Dose-Response Relationship | 2004 |
Protein fingerprints of anti-cancer effects of cyclin-dependent kinase inhibition: identification of candidate biomarkers using 2-D liquid phase separation coupled to mass spectrometry.
Topics: Animals; Antineoplastic Agents; Biomarkers; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; | 2005 |