bms345541 and Laryngeal-Neoplasms

Laryngeal carcinoma remains one of the most common malignancies, and curcumin has been proven to be effective against head and neck cancers in vitro. However, it has not yet been applied in clinical settings due to its low stability. In the current study, we synthesized 34 monocarbonyl analogues of curcumin with stable structures. CA15, which exhibited a stronger inhibited effect on laryngeal cancer cells HEp-2 but a lower toxicity on hepatic cells HL-7702 in MTT assay, was selected for further analysis. The effects of CA15 on cell viability, proliferation, migration, apoptosis, and NF-

Topics: Apoptosis; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Laryngeal Neoplasms; NF-kappa B; Quinoxalines; Tumor Necrosis Factor-alpha