bms-833923 and Basal-Cell-Nevus-Syndrome

bms-833923 has been researched along with Basal-Cell-Nevus-Syndrome* in 1 studies

Reviews

1 review(s) available for bms-833923 and Basal-Cell-Nevus-Syndrome

Article	Year
Emerging treatments and signaling pathway inhibitors. Seminars in cutaneous medicine and surgery, 2011, Volume: 30, Issue:4 Suppl A number of therapies that target components of the Hedgehog signaling pathway currently are in clinical trials. The specific molecules that seem most promising in basal cell carcinoma and a number of other cancers are those that target the Smoothened transmembrane protein. The pivotal phase II trials have been completed on the Smoothened inhibitor known as GDC-0449; five other agents (BMS-833923, LDE225, LEQ506, IPI926, and TAK-441) have also shown promise in animal studies and early clinical trials and have shown some efficacy in a variety of cancers that are affected by the Hedgehog signaling pathway. Topics: Aminoquinolines; Anilides; Antineoplastic Agents; Basal Cell Nevus Syndrome; Benzamides; Carcinoma, Basal Cell; Deoxyribonuclease (Pyrimidine Dimer); Fluorouracil; Hedgehog Proteins; Humans; Imiquimod; Photochemotherapy; Pyridines; Quinazolines; Retinoids; Secondary Prevention; Signal Transduction; Skin Neoplasms; Viral Proteins	2011

Article

Year

Emerging treatments and signaling pathway inhibitors.

Seminars in cutaneous medicine and surgery, 2011, Volume: 30, Issue:4 Suppl

A number of therapies that target components of the Hedgehog signaling pathway currently are in clinical trials. The specific molecules that seem most promising in basal cell carcinoma and a number of other cancers are those that target the Smoothened transmembrane protein. The pivotal phase II trials have been completed on the Smoothened inhibitor known as GDC-0449; five other agents (BMS-833923, LDE225, LEQ506, IPI926, and TAK-441) have also shown promise in animal studies and early clinical trials and have shown some efficacy in a variety of cancers that are affected by the Hedgehog signaling pathway.

Topics: Aminoquinolines; Anilides; Antineoplastic Agents; Basal Cell Nevus Syndrome; Benzamides; Carcinoma, Basal Cell; Deoxyribonuclease (Pyrimidine Dimer); Fluorouracil; Hedgehog Proteins; Humans; Imiquimod; Photochemotherapy; Pyridines; Quinazolines; Retinoids; Secondary Prevention; Signal Transduction; Skin Neoplasms; Viral Proteins

2011