bms-754807 and Small-Cell-Lung-Carcinoma

bms-754807 has been researched along with Small-Cell-Lung-Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for bms-754807 and Small-Cell-Lung-Carcinoma

Article	Year
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nature communications, 2019, 07-19, Volume: 10, Issue:1 Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and POU2F3 have been reported to identify the different subtypes of pulmonary NE cancers. Using a large-scale mass spectrometric approach, here we perform quantitative secretome analysis in 13 cell lines that signify the different NE lung cancer subtypes. We quantify 1,626 proteins and identify IGFBP5 as a secreted marker for ASCL1 Topics: Animals; Azepines; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Insulin-Like Growth Factor Binding Protein 5; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Neuroendocrine Tumors; Octamer Transcription Factors; Proteomics; Pyrazoles; Receptor, IGF Type 1; Signal Transduction; Small Cell Lung Carcinoma; Transcription Factors; Triazines; Triazoles	2019

Article

Year

Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells.

Nature communications, 2019, 07-19, Volume: 10, Issue:1

Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and POU2F3 have been reported to identify the different subtypes of pulmonary NE cancers. Using a large-scale mass spectrometric approach, here we perform quantitative secretome analysis in 13 cell lines that signify the different NE lung cancer subtypes. We quantify 1,626 proteins and identify IGFBP5 as a secreted marker for ASCL1

Topics: Animals; Azepines; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Insulin-Like Growth Factor Binding Protein 5; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Neuroendocrine Tumors; Octamer Transcription Factors; Proteomics; Pyrazoles; Receptor, IGF Type 1; Signal Transduction; Small Cell Lung Carcinoma; Transcription Factors; Triazines; Triazoles

2019