bms-599626 and Neoplasms

bms-599626 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bms-599626 and Neoplasms

Article	Year
Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 A novel series of 5-((4-aminopiperidin-1-yl)methyl)-pyrrolo[2,1-f][1,2,4]triazin-4-amines with small aniline substituents at the C4 position were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. Compound 8l exhibited promising oral efficacy in both EGFR and HER2-driven human tumor xenograft models. Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Humans; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Receptor, ErbB-2; Stomach Neoplasms; Triazines; Xenograft Model Antitumor Assays	2011

Article

Year

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2

A novel series of 5-((4-aminopiperidin-1-yl)methyl)-pyrrolo[2,1-f][1,2,4]triazin-4-amines with small aniline substituents at the C4 position were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. Compound 8l exhibited promising oral efficacy in both EGFR and HER2-driven human tumor xenograft models.

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Humans; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Receptor, ErbB-2; Stomach Neoplasms; Triazines; Xenograft Model Antitumor Assays

2011