bms-477118 and Diabetes-Mellitus

bms-477118 has been researched along with Diabetes-Mellitus* in 1 studies

Other Studies

1 other study(ies) available for bms-477118 and Diabetes-Mellitus

Article	Year
Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 The synthesis and biochemical evaluation of novel cyanothiazolidine inhibitors of dipeptidyl peptidase 4 (DPP4) is described. Their main structural feature is a constrained bicyclic core that prevents the intramolecular formation of inactive cyclic species. The inhibitors show good to moderate biochemical potency against DPP4 and display distinct selectivity profiles towards DPP7, DPP8 and DPP9 depending on their substitution. Topics: Azabicyclo Compounds; Catalysis; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Nitriles; Protein Structure, Tertiary; Pyrrolidines; Structure-Activity Relationship; Thiazoles; Thiazolidines; Time Factors	2009

Article

Year

Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.

Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

The synthesis and biochemical evaluation of novel cyanothiazolidine inhibitors of dipeptidyl peptidase 4 (DPP4) is described. Their main structural feature is a constrained bicyclic core that prevents the intramolecular formation of inactive cyclic species. The inhibitors show good to moderate biochemical potency against DPP4 and display distinct selectivity profiles towards DPP7, DPP8 and DPP9 depending on their substitution.

Topics: Azabicyclo Compounds; Catalysis; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Nitriles; Protein Structure, Tertiary; Pyrrolidines; Structure-Activity Relationship; Thiazoles; Thiazolidines; Time Factors

2009