bmn-111 and Lordosis

Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia, hypochondroplasia, and osteogenesis imperfecta are most frequent bone diseases. There is no curative treatment for these diseases, however, supportive therapies are available ; for example, growth-hormone therapy for achondroplasia and hypochondroplasia, and bisphosphonate therapy for osteogenesis imperfecta. In addition, enzyme replacement therapy for hypophosphatasia is now on clinical trial.

Topics: Achondroplasia; Alkaline Phosphatase; Animals; Bone and Bones; Bone Density Conservation Agents; Collagen Type I; Collagen Type I, alpha 1 Chain; Diphosphonates; Dwarfism; Humans; Hypophosphatasia; Limb Deformities, Congenital; Lordosis; Mice; Molecular Targeted Therapy; Mutation; Natriuretic Peptide, C-Type; Osteogenesis Imperfecta; Pamidronate; Receptor, Fibroblast Growth Factor, Type 3; Recombinant Proteins