bmap-27 has been researched along with Peritonitis* in 1 studies
1 other study(ies) available for bmap-27 and Peritonitis
Article | Year |
---|---|
In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs.
Two alpha-helical antimicrobial peptides (BMAP-27 and -28) and four synthetic analogs were compared for in vitro and in vivo antimicrobial efficacy. All peptides proved active in vitro at micromolar concentrations against a range of clinical isolates, including antibiotic-resistant strains. BMAP-27 and two analogs were more effective towards Gram-negative, and BMAP-28 towards Gram-positive organisms. In addition, BMAP-28 provided some protection in vitro against human herpes simplex virus type 1 (HSV-1). The parent peptides and mBMAP-28 analog protected mice from lethal i.p. infections in an acute peritonitis model at peptide doses significantly lower than those toxic to the animals, suggesting a satisfactory therapeutic index. Topics: Animals; Antimicrobial Cationic Peptides; Bacteria; Cathelicidins; Disease Models, Animal; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Peptide Fragments; Peritonitis; Protein Structure, Secondary; Proteins | 2003 |