blood-group-a-trisaccharide and Jaundice--Neonatal

ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.

Topics: ABO Blood-Group System; Adult; Alleles; Asian People; Blood Grouping and Crossmatching; Erythroblastosis, Fetal; Female; Humans; Immunoglobulin G; Infant, Newborn; Isoantibodies; Isoantigens; Jaundice, Neonatal; Male; Maternal-Fetal Exchange; Oligosaccharides; Oligosaccharides, Branched-Chain; Parity; Pedigree; Phenotype; Pregnancy; Trisaccharides