bleomycin and Lung-Neoplasms

bleomycin has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bleomycin and Lung-Neoplasms

Article	Year
Anticancer activity of koningic acid and semisynthetic derivatives. Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13 A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i) an extensive analysis of its anticancer potential in vitro and in vivo and (ii) the semi-synthesis of analogues to delineate structure-activity relationships. KA was characterized as a potent, but non-selective cytotoxic agent, active under both normoxic and hypoxic conditions and inactive in the A549 lung cancer xenograft model. According to our SAR, the acidic group could be replaced to keep bioactivity but an intact epoxide is essential. Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Fermentation; Glycolysis; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mice, Nude; Sesquiterpenes; Structure-Activity Relationship; Trichoderma; Tumor Burden; Xenograft Model Antitumor Assays	2015

Article

Year

Anticancer activity of koningic acid and semisynthetic derivatives.

Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i) an extensive analysis of its anticancer potential in vitro and in vivo and (ii) the semi-synthesis of analogues to delineate structure-activity relationships. KA was characterized as a potent, but non-selective cytotoxic agent, active under both normoxic and hypoxic conditions and inactive in the A549 lung cancer xenograft model. According to our SAR, the acidic group could be replaced to keep bioactivity but an intact epoxide is essential.

Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Fermentation; Glycolysis; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mice, Nude; Sesquiterpenes; Structure-Activity Relationship; Trichoderma; Tumor Burden; Xenograft Model Antitumor Assays

2015