bl-4162a and ST-Elevation-Myocardial-Infarction

Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative disorder that is characterized by the overproduction of platelets and a marked increase in the numbers of mature megakaryocytes present in the bone marrow. Thrombohemorrhagic disorders are major morbidities of ET, especially those with mutations in the gene encoding Janus kinase 2 (JAK2). In this study, we report the case of an 18-year-old patient with ET carrying JAK2 mutation who developed acute ST-elevation myocardial infarction (STEMI) 5 months after a commencement of anagrelide. Coronary endothelial dysfunction confirmed by positive acetylcholine provocation test lasted a year after the occurrence of STEMI. Furthermore, intracoronary imaging using optical coherence tomography demonstrated non-atheromatous intimal fibrosis possibly due to chronic endothelial damage. The coronary pathologies reflected chronic change potentially associated with properties of ET and JAK2 mutation in addition to hyperviscosity. These observations suggest that the side effect of anagrelide in our patient was considered causative, while underlying chronic endothelial dysfunction and adverse endothelial remodeling may be predisposing factors to his fatal cardiovascular events.

Topics: Acetylcholine; Adolescent; Coronary Angiography; Coronary Vessels; Echocardiography; Endothelium, Vascular; Fibrinolytic Agents; Fibrosis; Heart Function Tests; Humans; Janus Kinase 2; Magnetic Resonance Imaging; Male; Nitroglycerin; Percutaneous Coronary Intervention; Quinazolines; Radionuclide Imaging; ST Elevation Myocardial Infarction; Thrombectomy; Thrombocythemia, Essential; Tomography, Optical Coherence; Tunica Intima; Vasodilator Agents