bivalirudin and Respiratory-Syncytial-Virus-Infections

Respiratory syncytial virus (RSV) is the most common cause of small airways inflammation in the lungs (bronchiolitis) in neonates and immunocompromised adults. The deregulation of cellular and plasma components leads to increased morbidity and mortality. The activation of the clotting cascade plays a key role in the progression of disease severity during viral infection. The current investigation studied the effect of bivalirudin (BR) on the progression and cellular effects of RSV-induced infection in the neonatal mice model. Mice (5-7 days old) were inoculated intranasally with RSV with or without BR administration (2 mg kg

Topics: Animals; Animals, Newborn; Antiviral Agents; Cytokines; Disease Models, Animal; Lung; Mice; Mice, Inbred BALB C; MicroRNAs; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses