bisphenol-a-glucuronide and Asthma

Epidemiological studies have reported the relationship between bisphenol A (BPA) exposure and increased prevalence of asthma, but the mechanisms remain unclear. Here, we investigated whether BPA exposure and DNA methylation related to asthma in children. We collected urinary and blood samples from 228 children (Childhood Environment and Allergic Diseases Study cohort) aged 3 years. Thirty-three candidate genes potentially interacting with BPA exposure were selected from a toxicogenomics database. DNA methylation was measured in 22 blood samples with top-high and bottom-low exposures of BPA. Candidate genes with differential methylation levels were validated by qPCR and promoter associated CpG islands have been investigated. Correlations between the methylation percentage and BPA exposure and asthma were analyzed. According to our findings,

Topics: Asthma; Benzhydryl Compounds; Child, Preschool; Cohort Studies; CpG Islands; DNA Methylation; Female; Glucuronides; Humans; Male; Mitogen-Activated Protein Kinase 1; Phenols; Promoter Regions, Genetic