bismuth-tripotassium-dicitrate and Rosacea

Topics: Amoxicillin; Anti-Bacterial Agents; Case-Control Studies; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Organometallic Compounds; Rosacea; Severity of Illness Index; Stomach Ulcer

A higher prevalence of Helicobacter pylori infection in rosacea patients than in healthy controls has been reported.. The aim of this study was to investigate the effect of H. pylori eradication therapy in patients with rosacea.. Twenty-five rosacea patients and 87 age- and sex-matched healthy controls were included in this study. We detected IgG and IgA antibodies against H. pylori in both groups. An upper gastrointestinal endoscopy and a rapid urease test were performed on the 13 patients with rosacea who accepted this procedure. Amoxicillin 500 mg 3 times daily, metronidazole 500 mg 3 times daily, and bismuth subcitrate 300 mg 4 times daily were administered to patients positive for H. pylori. The severity of rosacea was scored before and after treatment.. There was no statistical difference in seropositivity in either group. In H. pylori-positive rosacea patients there was a significant decrease in the severity of rosacea at the end of the treatment as compared with the initial scores.. Our findings suggest that H. pylori may be involved in rosacea and that eradication treatment may be beneficial.

Topics: Adult; Aged; Amoxicillin; Antacids; Anti-Bacterial Agents; Antibodies, Bacterial; Bismuth; Female; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin A; Immunoglobulin G; Male; Metronidazole; Middle Aged; Organometallic Compounds; Rosacea; Treatment Outcome