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bisindolylmaleimide i and Muscle Relaxation

bisindolylmaleimide i has been researched along with Muscle Relaxation in 8 studies

bisindolylmaleimide I: a bis(indolyl)maleimide

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
"To examine the role of contractile agonist-induced activation of protein kinase C (PKC) in functional antagonism of airway smooth muscle contraction by beta-adrenoceptor agonists, we examined the effects of the specific PKC-inhibitor GF 109203X (2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide) on isoprenaline-induced relaxation of bovine tracheal smooth muscle contracted by various concentrations of methacholine and histamine."3.73Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C. ( Boterman, M; Elzinga, CR; Eppens, PB; Meurs, H; Wagemakers, D; Zaagsma, J, 2005)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maki, T1
Kajioka, S2
Itsumi, M1
Kareman, E1
Lee, K1
Shiota, M1
Eto, M1
Shahab, N1
Seki, N1
Naito, S2
Takahashi, R1
Nishimura, J1
Hirano, K1
Kanaide, H1
Oostendorp, J1
Obels, PP1
Terpstra, AR1
Nelemans, SA1
Zaagsma, J2
Boterman, M1
Elzinga, CR1
Wagemakers, D1
Eppens, PB1
Meurs, H1
Angulo, J1
Cuevas, P1
Fernández, A1
Allona, A1
Moncada, I1
Martín-Morales, A1
La Fuente, JM1
de Tejada, IS1
Patel, CA1
Rattan, S1
Kawabata, A1
Kuroda, R1
Kuroki, N1
Nishikawa, H1
Kawai, K1
Araki, H1

Other Studies

8 other studies available for bisindolylmaleimide i and Muscle Relaxation

ArticleYear
Mirabegron induces relaxant effects via cAMP signaling-dependent and -independent pathways in detrusor smooth muscle.
    Lower urinary tract symptoms, 2019, Volume: 11, Issue:2

    Topics: Acetanilides; Adenylyl Cyclase Inhibitors; Aged; Amides; Animals; Carbachol; Cyclic AMP; Female; Hum

2019
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
    Urology, 2012, Volume: 79, Issue:5

    Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Mus

2012
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle.
    The Journal of urology, 2003, Volume: 169, Issue:6

    Topics: Adrenergic alpha-Agonists; Amides; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Indoles

2003
Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C.
    European journal of pharmacology, 2004, Jul-08, Volume: 495, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Esophagus; E

2004
Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C.
    European journal of pharmacology, 2005, May-23, Volume: 516, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cattle; Colforsin; Dose-Response Relationship, Drug; Drug Synergi

2005
Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:2

    Topics: Alprostadil; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus; Endothelium; Erectile Dysfu

2006
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6

    Topics: ADP Ribose Transferases; Amides; Anal Canal; Animals; Botulinum Toxins; Carrier Proteins; Cells, Cul

2007
Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
    Life sciences, 2000, Oct-06, Volume: 67, Issue:20

    Topics: Androstadienes; Animals; Apamin; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug

2000