bisindolylmaleimide i has been researched along with Muscle Contraction in 45 studies
bisindolylmaleimide I: a bis(indolyl)maleimide
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prostate smooth muscle contraction is promoted by receptor-induced activation of intracellular signaling pathways." | 5.72 | Inhibition of human prostate smooth muscle contraction by the inhibitors of protein kinase C, GF109203X, and Go6983. ( Hennenberg, M; Huang, R; Li, B; Liu, Y; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R; Wang, R, 2022) |
| "To examine the role of contractile agonist-induced activation of protein kinase C (PKC) in functional antagonism of airway smooth muscle contraction by beta-adrenoceptor agonists, we examined the effects of the specific PKC-inhibitor GF 109203X (2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide) on isoprenaline-induced relaxation of bovine tracheal smooth muscle contracted by various concentrations of methacholine and histamine." | 3.73 | Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C. ( Boterman, M; Elzinga, CR; Eppens, PB; Meurs, H; Wagemakers, D; Zaagsma, J, 2005) |
| "Prostate smooth muscle contraction is promoted by receptor-induced activation of intracellular signaling pathways." | 1.72 | Inhibition of human prostate smooth muscle contraction by the inhibitors of protein kinase C, GF109203X, and Go6983. ( Hennenberg, M; Huang, R; Li, B; Liu, Y; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R; Wang, R, 2022) |
| "Interstitial cystitis is a syndrome characterized by detrusor overactivity and chronic inflammation of the bladder." | 1.48 | Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis. ( Bozkurt, TE; Denizalti, M; Durlu-Kandilci, NT; Sahin-Erdemli, I; Simsek, G, 2018) |
| "Interstitial cystitis is a chronic disease characterized by lower abdominal pain and some nonspecific symptoms including an increase in urinary frequency and urgency." | 1.46 | Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis. ( Anjum, I; Denizalti, M; Durlu-Kandilci, NT; Kandilci, HB; Sahin-Erdemli, I, 2017) |
| "Propofol can increase the PKC-mediated availability of nitric oxide but inhibit the novel PKC-regulated Ca-sensitization, which provides a novel explanation for the mechanism of propofol-induced vasodilation." | 1.42 | Protein Kinase C Isoforms Distinctly Regulate Propofol-induced Endothelium-dependent and Endothelium-independent Vasodilation. ( Cui, D; Wang, L; Wang, Y; Wu, B; Zhou, H; Zhou, Q, 2015) |
| "Bladder outlet obstruction was created by placement of a silver jeweler's jump rings loosely round the urethro-vesical junction of Guinea pigs." | 1.38 | Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle. ( Kajioka, S; Matsuda, M; Naito, S; Onimaru, M; Seki, N; Shahab, N; Takahashi-Yanaga, F, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (15.56) | 18.2507 |
| 2000's | 28 (62.22) | 29.6817 |
| 2010's | 9 (20.00) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, R | 1 |
| Liu, Y | 1 |
| Li, B | 1 |
| Wang, R | 1 |
| Tamalunas, A | 1 |
| Waidelich, R | 1 |
| Strittmatter, F | 1 |
| Stief, CG | 1 |
| Hennenberg, M | 1 |
| Anjum, I | 1 |
| Denizalti, M | 2 |
| Kandilci, HB | 1 |
| Durlu-Kandilci, NT | 2 |
| Sahin-Erdemli, I | 2 |
| Simsek, G | 1 |
| Bozkurt, TE | 1 |
| Singh, J | 1 |
| Rattan, S | 2 |
| Wang, Y | 1 |
| Zhou, H | 1 |
| Wu, B | 1 |
| Zhou, Q | 1 |
| Cui, D | 1 |
| Wang, L | 1 |
| Roosen, A | 1 |
| Fry, CH | 1 |
| Sui, G | 1 |
| Wu, C | 1 |
| Ratz, PH | 3 |
| Miner, AS | 2 |
| Shiraki, A | 1 |
| Kume, H | 1 |
| Oguma, T | 1 |
| Makino, Y | 1 |
| Ito, S | 2 |
| Shimokata, K | 1 |
| Honjo, H | 1 |
| Kamiya, K | 1 |
| Chang, S | 1 |
| Hypolite, JA | 1 |
| Mohanan, S | 1 |
| Zderic, SA | 1 |
| Wein, AJ | 1 |
| Chacko, S | 1 |
| Sakai, H | 2 |
| Kurihara, Y | 1 |
| Hashimoto, Y | 1 |
| Chiba, Y | 2 |
| Misawa, M | 2 |
| Clelland, LJ | 1 |
| Browne, BM | 1 |
| Alvarez, SM | 1 |
| Shahab, N | 2 |
| Kajioka, S | 2 |
| Takahashi-Yanaga, F | 1 |
| Onimaru, M | 1 |
| Matsuda, M | 1 |
| Seki, N | 3 |
| Naito, S | 4 |
| MacDonald, JA | 2 |
| Moffat, LD | 1 |
| Al-Ghabkari, A | 1 |
| Sutherland, C | 1 |
| Walsh, MP | 2 |
| Civelek, M | 1 |
| Ainslie, K | 1 |
| Garanich, JS | 1 |
| Tarbell, JM | 1 |
| Meehl, JT | 1 |
| Eddinger, TJ | 1 |
| Cloutier, M | 1 |
| Campbell, S | 1 |
| Basora, N | 1 |
| Proteau, S | 1 |
| Payet, MD | 1 |
| Rousseau, E | 2 |
| Takahashi, R | 2 |
| Nishimura, J | 2 |
| Hirano, K | 2 |
| Kanaide, H | 2 |
| Donsmark, M | 1 |
| Langfort, J | 1 |
| Holm, C | 1 |
| Ploug, T | 1 |
| Galbo, H | 1 |
| El Sayah, M | 1 |
| Calixto, JB | 1 |
| Ozaki, H | 1 |
| Yasuda, K | 1 |
| Kim, YS | 1 |
| Egawa, M | 1 |
| Kanzaki, H | 1 |
| Nakazawa, H | 1 |
| Hori, M | 1 |
| Seto, M | 1 |
| Karaki, H | 1 |
| Rohra, DK | 1 |
| Yamakuni, T | 1 |
| Saito, SY | 1 |
| Ohizumi, Y | 1 |
| Oostendorp, J | 1 |
| Obels, PP | 1 |
| Terpstra, AR | 1 |
| Nelemans, SA | 1 |
| Zaagsma, J | 2 |
| Kim, J | 2 |
| Lee, YR | 1 |
| Lee, CH | 1 |
| Choi, WH | 1 |
| Lee, CK | 1 |
| Bae, YM | 1 |
| Cho, S | 1 |
| Kim, B | 1 |
| Boterman, M | 1 |
| Elzinga, CR | 1 |
| Wagemakers, D | 1 |
| Eppens, PB | 1 |
| Meurs, H | 1 |
| Hichami, A | 1 |
| Morin, C | 1 |
| Khan, NA | 1 |
| Mustafa, S | 1 |
| Oriowo, M | 1 |
| Xie, Z | 1 |
| Su, W | 1 |
| Guo, Z | 1 |
| Pang, H | 1 |
| Post, SR | 1 |
| Gong, MC | 1 |
| Hong, Z | 1 |
| Hong, F | 1 |
| Olschewski, A | 1 |
| Cabrera, JA | 1 |
| Varghese, A | 1 |
| Nelson, DP | 1 |
| Weir, EK | 1 |
| Poole, DP | 1 |
| Furness, JB | 1 |
| Patel, CA | 1 |
| Ihara, E | 1 |
| Moffat, L | 1 |
| Ostrander, J | 1 |
| Yamamoto, M | 1 |
| Yang, KX | 1 |
| Black, JL | 1 |
| Zheng, XL | 1 |
| Hollenberg, MD | 1 |
| Satoh, M | 1 |
| Hayasaka, M | 1 |
| Horiuchi, K | 1 |
| Takayanagi, I | 1 |
| Zagorodnyuk, V | 1 |
| Santicioli, P | 1 |
| Maggi, CA | 1 |
| Pype, JL | 1 |
| Mak, JC | 1 |
| Dupont, LJ | 1 |
| Verleden, GM | 1 |
| Barnes, PJ | 1 |
| Yuasa, U | 1 |
| Mino, T | 1 |
| Naka, M | 1 |
| Yada, I | 1 |
| Tanaka, T | 1 |
| Yang, ZW | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Ryder, JW | 1 |
| Fahlman, R | 1 |
| Wallberg-Henriksson, H | 1 |
| Alessi, DR | 1 |
| Krook, A | 1 |
| Zierath, JR | 1 |
| Kitazawa, T | 2 |
| Eto, M | 2 |
| Woodsome, TP | 1 |
| Brautigan, DL | 2 |
| Kawabata, A | 1 |
| Kuroda, R | 1 |
| Kuroki, N | 1 |
| Nishikawa, H | 1 |
| Kawai, K | 1 |
| Araki, H | 1 |
| Yazawa, M | 1 |
| Mukai, H | 1 |
| Ono, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
45 other studies available for bisindolylmaleimide i and Muscle Contraction
| Article | Year |
|---|---|
Inhibition of human prostate smooth muscle contraction by the inhibitors of protein kinase C, GF109203X, and Go6983.
Topics: Humans; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction | 2022 |
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Topics: Amides; Animals; Calcium; Cystitis; Female; Gene Expression Regulation; Indoles; Lysophospholipids; | 2017 |
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis.
Topics: Amides; Animals; Carbachol; Cholinergic Agonists; Cystitis, Interstitial; Enzyme Inhibitors; Heparin | 2018 |
Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle.
Topics: Amides; Animals; Carcinogens; Enzyme Inhibitors; Fecal Incontinence; Indoles; Maleimides; Muscle Con | 2013 |
Protein Kinase C Isoforms Distinctly Regulate Propofol-induced Endothelium-dependent and Endothelium-independent Vasodilation.
Topics: Anesthetics, Intravenous; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Down-Regulation; Endot | 2015 |
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contra | 2009 |
Role of protein kinase Czeta and calcium entry in KCl-induced vascular smooth muscle calcium sensitization and feedback control of cellular calcium levels.
Topics: Animals; Calcium; Cells, Cultured; Feedback; Indoles; Maleimides; Muscle Contraction; Muscle, Smooth | 2009 |
Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Bridged-Ring Co | 2009 |
Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder.
Topics: Animals; Disease Models, Animal; Humans; Hypertrophy; In Vitro Techniques; Indoles; Male; Maleimides | 2009 |
Phorbol 12,13-dibutyrate-mediated contraction of the stimulated bronchial smooth muscles of mice.
Topics: Acetylcholine; Animals; Bronchi; Calcimycin; Cysteine Endopeptidases; Dose-Response Relationship, Dr | 2010 |
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cardiovascular Agents; Dose-Respons | 2011 |
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Guinea Pigs; Indoles; Male; Maleimides; Musc | 2012 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Mus | 2012 |
Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Arteries; Blotting, Western; Calcium-Calmodulin-Depe | 2013 |
Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism.
Topics: ADP Ribose Transferases; Animals; Aorta; Blood Flow Velocity; Botulinum Toxins; Calcium Signaling; E | 2002 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol | 2002 |
20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle.
Topics: Animals; Bronchi; Calcium; Cations; Diglycerides; Enzyme Inhibitors; Guinea Pigs; Hydroxyeicosatetra | 2003 |
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Indoles | 2003 |
Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Blotting, Western; Electric Stimulation; Enzyme Activ | 2003 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Re | 2003 |
Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.
Topics: Adult; Blotting, Western; Calcium; Carbazoles; Enzyme Activators; Enzyme Inhibitors; Female; Humans; | 2003 |
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Topics: Animals; Aorta, Thoracic; Bridged-Ring Compounds; Butadienes; Drug Synergism; Estrenes; Flavonoids; | 2004 |
Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Esophagus; E | 2004 |
Ca2+ sensitization in contraction of human bladder smooth muscle.
Topics: Aged; Amides; Calcium; Female; Humans; In Vitro Techniques; Indoles; Intracellular Signaling Peptide | 2004 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, | 2005 |
Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C.
Topics: Adrenergic beta-Agonists; Animals; Cattle; Colforsin; Dose-Response Relationship, Drug; Drug Synergi | 2005 |
Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone.
Topics: Animals; Bronchi; Calcium; Calcium Channel Blockers; Cells, Cultured; Diglycerides; Docosahexaenoic | 2005 |
Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Capsaicin; Cold Temperature; Enzyme Activation; | 2005 |
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cells, Cultured; Diabetes Mel | 2006 |
Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus.
Topics: Animals; Arachidonic Acids; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels, L- | 2006 |
PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle.
Topics: Animals; Carbachol; Cytoplasm; Cytoskeleton; Diacylglycerol Kinase; Diterpenes; Female; Guinea Pigs; | 2007 |
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.
Topics: ADP Ribose Transferases; Amides; Anal Canal; Animals; Botulinum Toxins; Carrier Proteins; Cells, Cul | 2007 |
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Calcium-Calmodulin-Dependent Prot | 2007 |
Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine.
Topics: Acetophenones; Acetylcholine; Animals; Benzopyrans; Bronchi; Carbazoles; Dose-Response Relationship, | 2008 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techn | 1995 |
Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.
Topics: 1-Propanol; Animals; Calcium; Catechols; Cyclohexanones; Enzyme Inhibitors; Epidermal Growth Factor; | 1997 |
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic | 1998 |
Evidence for the involvement of multiple mechanisms in the excitatory action of bradykinin in the circular muscle of guinea-pig colon.
Topics: Animals; Apamin; Bradykinin; Calcium; Calcium Channel Blockers; Colon; Enzyme Inhibitors; Guinea Pig | 1998 |
Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle.
Topics: Animals; Blotting, Northern; Cattle; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activ | 1998 |
Regulatory mechanisms of calponin phosphorylation in endothelin-1-induced contraction of porcine coronary artery.
Topics: Animals; Arteries; Calcium-Binding Proteins; Calponins; Coronary Vessels; Endothelin-1; Enzyme Inhib | 1999 |
Low extracellular Mg2+ contraction of arterial muscle: role of protein kinase C and protein tyrosine phosphorylation.
Topics: Animals; Aorta, Thoracic; Arteries; Calcium; Carbazoles; Dose-Response Relationship, Drug; Endotheli | 1999 |
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme | 2000 |
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility.
Topics: Amides; Animals; Cell Membrane Permeability; Enzyme Inhibitors; Femoral Artery; GTP-Binding Proteins | 2000 |
Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
Topics: Androstadienes; Animals; Apamin; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug | 2000 |
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; C | 2001 |