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bisindolylmaleimide i and Ache

bisindolylmaleimide i has been researched along with Ache in 10 studies

bisindolylmaleimide I: a bis(indolyl)maleimide

Research Excerpts

ExcerptRelevanceReference
"Male Swiss Webster mice exhibited antinociception, hypothermia and Straub tail 3h following a 75mg morphine pellet implantation."3.73PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice. ( Dewey, WL; Gabra, BH; Javed, RR; Smith, FL; Smith, PA, 2006)
"In contrast, thermal hyperalgesia during spontaneous withdrawal was inhibited by both PKC and gamma inhibitors."1.32Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. ( Allen, CP; Kendig, JJ; Mochly-Rosen, D; Sweitzer, SM; Tjolsen, A; Wong, SM, 2004)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's6 (60.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fu, Y1
Han, J1
Ishola, T1
Scerbo, M1
Adwanikar, H1
Ramsey, C1
Neugebauer, V1
Zhang, L1
Hammond, DL1
Silva, MA1
Klafke, JZ1
Rossato, MF1
Gewehr, C1
Guerra, GP1
Rubin, MA1
Ferreira, J1
Wang, S1
Dai, Y1
Kobayashi, K1
Zhu, W1
Kogure, Y1
Yamanaka, H1
Wan, Y1
Zhang, W1
Noguchi, K1
Smith, FL2
Javed, RR2
Elzey, MJ1
Dewey, WL2
Sweitzer, SM1
Wong, SM1
Tjolsen, A1
Allen, CP1
Mochly-Rosen, D1
Kendig, JJ1
Smith, PA1
Gabra, BH1
Yashpal, K1
Pitcher, GM1
Parent, A1
Quirion, R1
Coderre, TJ1
Hua, XY1
Chen, P1
Yaksh, TL1
Souza, AL1
Moreira, FA1
Almeida, KR1
Bertollo, CM1
Costa, KA1
Coelho, MM1

Other Studies

10 other studies available for bisindolylmaleimide i and Ache

ArticleYear
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
    Molecular pain, 2008, Jul-16, Volume: 4

    Topics: Amygdala; Animals; Arthritis; Behavior; Butadienes; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-De

2008
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
    Journal of neurophysiology, 2009, Volume: 102, Issue:2

    Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Inhibitors; Excita

2009
Role of peripheral polyamines in the development of inflammatory pain.
    Biochemical pharmacology, 2011, Aug-01, Volume: 82, Issue:3

    Topics: Animals; Eflornithine; Gene Expression Regulation, Enzymologic; Indoles; Inflammation; Male; Maleimi

2011
Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.
    The European journal of neuroscience, 2012, Volume: 36, Issue:3

    Topics: Adenosine Triphosphate; Animals; Carbazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gangli

2012
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.
    Brain research, 2003, Sep-19, Volume: 985, Issue:1

    Topics: Analgesics; Animals; Brain; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relation

2003
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.
    Pain, 2004, Volume: 110, Issue:1-2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Drug Interactions; Enzyme Inhibit

2004
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
    Pharmacological research, 2006, Volume: 54, Issue:6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Carbazoles; Cyclic AMP-Dependent Pr

2006
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 1

    Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Formaldehyde; Functional Laterality;

1995
Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats.
    Neuroscience letters, 1999, Dec-03, Volume: 276, Issue:2

    Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibito

1999
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: Alkaloids; Animals; Benzophenanthridines; Bradykinin; Dose-Response Relationship, Drug; Enzyme Inhib

2002