bisdemethoxycurcumin has been researched along with Leukemia* in 2 studies
2 other study(ies) available for bisdemethoxycurcumin and Leukemia
| Article | Year |
|---|---|
Dietary Turmeric Bisdemethoxycurcumin Suppresses Wilms' Tumor 1 and CD34 Protein Expressions in KG-1a Leukemic Stem Cells.
Leukemic cells remaining in the body is the main problem for cancer patients, and these cells are called Leukemic Stem Cells (LSCs). Many studies have revealed that the overexpression of the Wilms' tumor 1 (WT1) protein is related to leukemogenesis. Curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) from Thai turmeric ( Topics: Antigens, CD34; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Curcuma; Curcumin; Diarylheptanoids; Humans; K562 Cells; Leukemia; Leukocytes, Mononuclear; Microscopy, Fluorescence; Neoplastic Stem Cells; WT1 Proteins | 2019 |
Curcumin is a potent DNA hypomethylation agent.
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line. Topics: Catalysis; Catalytic Domain; Cell Line, Tumor; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Drug Design; Humans; Inhibitory Concentration 50; Leukemia; Models, Chemical; Molecular Conformation | 2009 |