bisbenzimidazole has been researched along with Neuroblastoma in 6 studies
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cells of the neuroblastoma line N2a (Neuro2a cells) were divided into three experimental groups: control, bupivacaine-treated, and bupivacaine-treated with GM-1 pretreatment." | 7.83 | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. ( He, Y; Ji, J; Liang, Y; Lin, Y; Liu, J, 2016) |
| "Cells of the neuroblastoma line N2a (Neuro2a cells) were divided into three experimental groups: control, bupivacaine-treated, and bupivacaine-treated with GM-1 pretreatment." | 3.83 | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. ( He, Y; Ji, J; Liang, Y; Lin, Y; Liu, J, 2016) |
| " Using SH-SY5Y, a human neuroblastoma cell line, we demonstrated that 6-OHDA toxicity was determined by the amount of p-quinone produced in 6-OHDA auto-oxidation rather than by reactive oxygen species (ROS)." | 3.73 | p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. ( Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sakka, N; Sawada, H; Shimohama, S; Yamamoto, N, 2005) |
| " Salvianic acid A (SA), isolated from the Chinese herbal medicine Salvia miltiorrhiza, is capable of protecting diverse kinds of cells from damage caused by a variety of toxic stimuli." | 1.33 | Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. ( Wang, XJ; Xu, JX, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iglesias-Guimarais, V | 1 |
| Gil-Guiñon, E | 1 |
| Sánchez-Osuna, M | 1 |
| Casanelles, E | 1 |
| García-Belinchón, M | 1 |
| Comella, JX | 1 |
| Yuste, VJ | 1 |
| Liang, Y | 1 |
| Ji, J | 1 |
| Lin, Y | 1 |
| He, Y | 1 |
| Liu, J | 1 |
| Wang, XJ | 1 |
| Xu, JX | 1 |
| Izumi, Y | 1 |
| Sawada, H | 1 |
| Sakka, N | 1 |
| Yamamoto, N | 1 |
| Kume, T | 1 |
| Katsuki, H | 1 |
| Shimohama, S | 1 |
| Akaike, A | 1 |
| Cervio, E | 1 |
| Volta, U | 1 |
| Verri, M | 1 |
| Boschi, F | 1 |
| Pastoris, O | 1 |
| Granito, A | 1 |
| Barbara, G | 1 |
| Parisi, C | 1 |
| Felicani, C | 1 |
| Tonini, M | 1 |
| De Giorgio, R | 1 |
| Lee, MW | 1 |
| Park, SC | 1 |
| Chae, HS | 1 |
| Bach, JH | 1 |
| Lee, HJ | 1 |
| Lee, SH | 1 |
| Kang, YK | 1 |
| Kim, KY | 1 |
| Lee, WB | 1 |
| Kim, SS | 1 |
6 other studies available for bisbenzimidazole and Neuroblastoma
| Article | Year |
|---|---|
Chromatin collapse during caspase-dependent apoptotic cell death requires DNA fragmentation factor, 40-kDa subunit-/caspase-activated deoxyribonuclease-mediated 3'-OH single-strand DNA breaks.
Topics: Animals; Apoptosis; Bisbenzimidazole; Caspases; Cell Death; Cell Line; Cell Nucleus; Chromatin; Clon | 2013 |
The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells.
Topics: Animals; Apoptosis; Bisbenzimidazole; Blotting, Western; Bupivacaine; Cell Line, Tumor; Cell Surviva | 2016 |
Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Bisbenzimidazole; Blotting, West | 2005 |
p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
Topics: Analysis of Variance; Animals; Antioxidants; Benzoquinones; Bisbenzimidazole; Caspase 3; Caspases; C | 2005 |
Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro.
Topics: Adult; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Bisbenzimidazo | 2007 |
The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis.
Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Caspases; Cell Line; Cell Survival; Cytoprotection; | 2001 |