bisbenzimidazole has been researched along with Melanoma in 6 studies
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hoechst 33258 itself was selectively toxic for the MM96E melanoma cell line compared with other cell lines, induced a highly dendritic morphology, increased tyrosinase activity and tyrosinase mRNA but decreased the level of gp75 (TRP-1) mRNA; message for a third pigment gene, Pmel-17, was unchanged." | 5.29 | Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells. ( Danoy, PA; Dong, Y; Dunn, IS; Jacobs, JJ; Kaushal, A; McGregor, K; Michel, J; Sturm, RA; Wong, SS; Zhang, XM, 1994) |
| " Hoechst 33258 itself was selectively toxic for the MM96E melanoma cell line compared with other cell lines, induced a highly dendritic morphology, increased tyrosinase activity and tyrosinase mRNA but decreased the level of gp75 (TRP-1) mRNA; message for a third pigment gene, Pmel-17, was unchanged." | 1.29 | Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells. ( Danoy, PA; Dong, Y; Dunn, IS; Jacobs, JJ; Kaushal, A; McGregor, K; Michel, J; Sturm, RA; Wong, SS; Zhang, XM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, SS | 1 |
| Sturm, RA | 1 |
| Michel, J | 1 |
| Zhang, XM | 1 |
| Danoy, PA | 1 |
| McGregor, K | 1 |
| Jacobs, JJ | 1 |
| Kaushal, A | 1 |
| Dong, Y | 1 |
| Dunn, IS | 1 |
| Poot, M | 1 |
| Hiller, KH | 1 |
| Heimpel, S | 1 |
| Schuster, A | 1 |
| Köhler, J | 1 |
| Hoehn, H | 1 |
| Dow, AI | 1 |
| Shafer, SA | 1 |
| Kirkwood, JM | 1 |
| Mascari, RA | 1 |
| Waggoner, AS | 1 |
| Greene, JF | 1 |
| Morgan, CD | 1 |
| Rao, A | 1 |
| Amoss, MS | 1 |
| Arguello, F | 1 |
| Finlay, GJ | 1 |
| Baguley, BC | 1 |
| Freed, WJ | 1 |
| Adinolfi, AM | 1 |
| Laskin, JD | 1 |
| Geller, HM | 1 |
6 other studies available for bisbenzimidazole and Melanoma
| Article | Year |
|---|---|
Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells.
Topics: Base Sequence; Benzimidazoles; Bisbenzimidazole; Cell Cycle; Cell Differentiation; Cell Survival; Ch | 1994 |
Heterogeneity of bromodeoxyuridine sensitivity of cultured cells from melanoma metastases.
Topics: Bisbenzimidazole; Bromodeoxyuridine; Cell Division; Ethidium; Flow Cytometry; G2 Phase; Genetic Hete | 1995 |
Automatic multiparameter fluorescence imaging for determining lymphocyte phenotype and activation status in melanoma tissue sections.
Topics: Antigens, CD; Automation; Biopsy; Bisbenzimidazole; Color; Fluorescent Dyes; HLA-DR Antigens; Humans | 1996 |
Regression by differentiation in the Sinclair swine model of cutaneous melanoma.
Topics: Animals; Bisbenzimidazole; Cell Differentiation; Disease Models, Animal; Humans; Male; Melanoma; Mic | 1997 |
Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Benzimidazoles; Bisbenzimidazole; Colonic Neop | 1990 |
Transplantation of B16/C3 melanoma cells into the brains of rats and mice.
Topics: Animals; Bisbenzimidazole; Brain; Catecholamines; Cell Line; DNA, Neoplasm; Fluorescent Dyes; Melano | 1989 |