bisbenzimidazole has been researched along with Amyotrophic Lateral Sclerosis in 2 studies
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigini, P | 2 |
| Veglianese, P | 1 |
| Andriolo, G | 1 |
| Cova, L | 2 |
| Grignaschi, G | 1 |
| Caron, I | 1 |
| Daleno, C | 1 |
| Barbera, S | 2 |
| Ottolina, A | 1 |
| Calzarossa, C | 1 |
| Lazzari, L | 1 |
| Mennini, T | 2 |
| Bendotti, C | 1 |
| Silani, V | 2 |
| Diana, V | 1 |
| Fumagalli, E | 1 |
| Micotti, E | 1 |
| Sitia, L | 1 |
| Paladini, A | 1 |
| Bisighini, C | 1 |
| De Grada, L | 1 |
| Coloca, L | 1 |
| Colombo, L | 1 |
| Manca, P | 1 |
| Bossolasco, P | 1 |
| Malvestiti, F | 1 |
| Fiordaliso, F | 1 |
| Forloni, G | 1 |
| Morbidelli, M | 1 |
| Salmona, M | 1 |
| Giardino, D | 1 |
| Moscatelli, D | 1 |
2 other studies available for bisbenzimidazole and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Intracerebroventricular administration of human umbilical cord blood cells delays disease progression in two murine models of motor neuron degeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Bisbenzimidazole; Cell- and Tissue-Based Therapy; Cytokines; | 2011 |
Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease.
Topics: Amniotic Fluid; Amyotrophic Lateral Sclerosis; Animals; Bisbenzimidazole; Brain; Cell Nucleus; Cell | 2012 |