bisabolol has been researched along with Pruritus* in 2 studies
2 trial(s) available for bisabolol and Pruritus
Article | Year |
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Effect of topical heparin and levomenol on atopic dermatitis: a randomized four-arm, placebo-controlled, double-blind clinical study.
The aim of the controlled double-blind trial was to demonstrate the superiority of a topical combination product over its single constituents.. A total of 278 patients with atopic dermatitis were randomized into four groups: 79 patients were treated with a topical combination of levomenol and heparin (A), 80 patients with levomenol alone (B), 78 patients with heparin alone (C) and 41 patients with the cream base with no active substances (D). The medication was applied twice daily for 8weeks. Efficacy criteria included the severity of pruritus (visual analogue scale, VAS) and the SCORing Atopic Dermatitis (SCORAD) index as well as the overall assessment of efficacy and tolerance by both physician and patient.. The improvement of pruritus and SCORAD values in Group A was significantly higher compared with Groups B-D (ancova, P<7×10(-8) ). The improvement of pruritus in Group A approximately corresponded to the cumulative effect of the two single active substances, with mean improvements of itching of -41.3, -13.3, -21.3 and +0.6mm VAS in Groups A-D, respectively (95% CI 7.1-13.5, 2.9-9.2 and 10.4-18.3mm for the comparisons A vs. B, A vs. C and A vs. D).. The combination of levomenol and heparin proved to be significantly more efficacious in the treatment of pruritus and inflamed skin than the preparations of the single components. Topics: Administration, Cutaneous; Adolescent; Adult; Child; Child, Preschool; Dermatitis, Atopic; Double-Blind Method; Drug Combinations; Female; Fibrinolytic Agents; Heparin; Humans; Infant; Male; Middle Aged; Monocyclic Sesquiterpenes; Patient Satisfaction; Pruritus; Sesquiterpenes; Severity of Illness Index; Young Adult | 2011 |
Proof of efficacy of Kamillosan(R) cream in atopic eczema.
Kamillosan(R) cream contains chamomile extract as active principle manufactured from the chamomile sort Manzana which is rich in active principles and has been proved not to exhibit a chamomile-related allergen potential. For this reason Kamillosan(R) cream is suited for local therapy of atopic eczema. In a partially double-blind, randomized study carried out as a half-side comparison, Kamillosan(R) cream was tested vs. 0.5% hydrocortisone cream and the vehicle cream as placebo in patients suffering from medium-degree atopic eczema. After a 2-week treatment Kamillosan(R) cream showed a mild superiority towards 0.5% hydrocortisone and a marginal difference as compared to placebo. Topics: Administration, Topical; Anti-Inflammatory Agents; Arachidonic Acid; Arm; Chamomile; Dermatitis, Atopic; Drug Combinations; Erythema; Humans; Hydrocortisone; Middle Aged; Oils, Volatile; Phytotherapy; Plant Extracts; Plants, Medicinal; Pruritus; Sesquiterpenes; Treatment Outcome | 2000 |