bisabolol and Chronic-Disease

Ozone therapy has a large clinical application in many therapeutic areas because of its well-known antimicrobial, immunological, and oxygenating properties. Recently, interest has grown regarding the application of ozonated oil for vascular leg ulcer treatment. The efficacy of an innovative spray formulation of ozonated oil and α-bisabolol combination in the topical treatment of chronic venous leg ulcers was evaluated compared with standard epithelialization cream.. A randomized controlled trial was conducted.. A total of 29 patients older than 18 years with chronic venous leg ulcers for less than 2 years' duration were assessed.. Patients were randomized to receive daily application of both ozonated oil and α-bisabolol or the control cream (vitamin A, vitamin E, talc, and zinc oxide) for 30 days.. Patients were evaluated on 4 different visits: at days 0, 7, 14, and 30. At each visit, the wound surfaces were measured. Wound area ratio and the speed of ulcer healing were calculated.. At the end of treatment, the proportion of patients with complete ulcer healing was higher with ozonated oil and α-bisabolol formulation (25% vs 0%). Furthermore, the changes in ulcer surface area were significant for ozonated oil and α-bisabolol formulation only (P < .05), in particular, observing a significant and progressive reduction of the wound surface by 34%, 59%, and 73%, after 7, 14, and 30 days of treatment, respectively.. The innovative spray formulation of ozonated oil and α-bisabolol combination shows promise as an important new therapeutic option in the adjuvant treatment of venous ulcers.

Topics: Administration, Topical; Aerosols; Chronic Disease; Dermatologic Agents; Female; Humans; Leg Ulcer; Male; Middle Aged; Monocyclic Sesquiterpenes; Ozone; Plant Oils; Sesquiterpenes; Skin Cream; Sunflower Oil; Varicose Ulcer; Wound Healing

So-called anti-irritants (AI) are widely used in cosmetic formulations, with the aim of reducing irritation from substances in the formulation. It may also be claimed that they are 'soothing' and 'healing' ingredients. However, the proof for these claims is circumstantial. The dose-response effect of 4 alleged AI (nifedipine, (-)-alpha-bisabolol, canola oil and glycerol) was studied on experimentally induced acute irritation in healthy volunteers, and only glycerol showed dose-related response and effects potentially better than no treatment. The acute irritation model only allowed a small window of opportunity in which to demonstrate efficacy. Therefore, the effect of AI was studied in a cumulative irritation model by inducing irritant dermatitis with 10 min daily exposures for 5+4 days (no irritation on weekend) to 1% sodium lauryl sulfate on the right and 20% nonanoic acid on the left volar forearm. AI ointments were applied twice daily. Clinical scoring was performed daily, evaporimetry (Trans Epidermal Water Loss), hydration and colourimetry were measured at baseline (D0), in the middle and at the end of treatment. The glycerol ointment was the only treatment statistically better than both 'no treatment' and vehicle.

Topics: Adult; Chemistry, Pharmaceutical; Chronic Disease; Dermatitis, Irritant; Dose-Response Relationship, Drug; Double-Blind Method; Fatty Acids; Fatty Acids, Monounsaturated; Female; Glycerol; Humans; Irritants; Male; Monocyclic Sesquiterpenes; Nifedipine; Rapeseed Oil; Reference Values; Sesquiterpenes; Sodium Dodecyl Sulfate; Surface-Active Agents; Water Loss, Insensible