birb 796 has been researched along with Pulmonary Disease, Chronic Obstructive in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bunnage, ME; Burrows, JL; Butcher, KJ; Dodd, PG; Evans, TJ; Fairman, DA; Hughes, SJ; Kilty, IC; Lemaitre, A; Lewthwaite, RA; Mahnke, A; Mathias, JP; Millan, DS; Philip, J; Phillips, C; Smith, RT; Stefaniak, MH; Yeadon, M | 1 |
| Brown, RJ; Charron, CE; Colucci, M; Frickel, F; Hardy, G; Ito, K; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Onions, ST; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG | 1 |
| Khalaf, RM; Lea, SR; Metcalfe, HJ; Singh, D | 1 |
| Brindley, C; Charron, CE; Ito, K; Kizawa, Y; Lea, S; Russell, P; Singh, D | 1 |
| Higham, A; Lea, S; Ray, D; Singh, D | 1 |
| Armstrong, J; Booth, G; Cadden, P; Harbron, C; Lea, S; Singh, D; Wreggett, KA | 1 |
| Dougall, IG; Ratcliffe, MJ | 1 |
| Alevy, YG; Brett, TJ; Byers, DE; Heier, RF; Holtzman, MJ; Miller, CA; Patel, AC; Patel, DA; Romero, AG; Roswit, WT; Tucker, J | 1 |
1 trial(s) available for birb 796 and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.
Topics: Adrenal Cortex Hormones; Adult; Aged; Animals; Anti-Inflammatory Agents; Cigarette Smoking; Disease Models, Animal; Double-Blind Method; Epithelial Cells; Female; Forced Expiratory Volume; Humans; Macrophages; Male; Mice; Middle Aged; Monocytes; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Sputum; United Kingdom | 2017 |
7 other study(ies) available for birb 796 and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Binding Sites; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Stability; Humans; In Vitro Techniques; Kinetics; Leukocytes, Mononuclear; Methylurea Compounds; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Conformation; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Rats; Solubility; Surface Plasmon Resonance; Tumor Necrosis Factor-alpha | 2011 |
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Topics: Animals; Asthma; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Disease, Chronic Obstructive; Steroids; Structure-Activity Relationship; U937 Cells | 2016 |
Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi.
Topics: Adrenal Cortex Hormones; Aged; Cells, Cultured; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance; Haemophilus Infections; Humans; Macrophages; Naphthalenes; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pyrazoles | 2017 |
Corticosteroid effects on COPD alveolar macrophages: dependency on cell culture methodology.
Topics: Aged; Blotting, Western; Cell Culture Techniques; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dexamethasone; Enzyme-Linked Immunosorbent Assay; Female; Glucocorticoids; Humans; Interleukin-8; Lipopolysaccharides; Macrophages, Alveolar; Male; Middle Aged; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2014 |
Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents; Blotting, Western; Bronchoscopy; Cells, Cultured; Chemokines; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; HSP27 Heat-Shock Proteins; Humans; Immunoassay; Lipopolysaccharides; Macrophages, Alveolar; Male; Middle Aged; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Smoking; Young Adult | 2011 |
Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages.
Topics: Anti-Inflammatory Agents; Budesonide; Cells, Cultured; Cyclohexanecarboxylic Acids; Female; Humans; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; Male; Middle Aged; Naphthalenes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Tumor Necrosis Factor-alpha | 2012 |
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
Topics: Binding Sites; Cells, Cultured; Chloride Channels; Crystallography, X-Ray; Drug Design; Epithelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Hydrogen Bonding; Interleukin-13; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 13; Models, Molecular; Mucins; Mucus; Naphthalenes; Protein Binding; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Respiratory System; RNA Interference; Secretory Pathway | 2012 |