biphenylylacetic-acid and Wounds-and-Injuries

A double-blind study vs placebo was carried out on 82 pts suffering from soft tissue trauma, to evaluate the efficacy and tolerance of a new anti-inflammatory, non-steroidal analgesic for topical use, 3% BPAA. Clinical results obtained by the group treated with BPAA gel were highly significant (p = 0.01) and positive, showing absence of local and systemic side-effects. Accordingly, BPAA gel can be recommended for treatment of soft tissue trauma.

Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Evaluation; Female; Gels; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phenylacetates; Wounds and Injuries

Two hundred and thirty-one patients with acute soft tissue injuries were treated in a double-blind placebo-controlled study of felbinac (biphenylacetic acid) gel applied three times daily to the injured site. Those treated with felbinac had significantly greater improvement at Day 4 (p less than 0.001) and Day 7 (p less than 0.02) than those who received placebo. Patients' self-assessment diary cards confirmed superiority of the active treatment as early as Day 2 of the study. Local skin reactions were few (three per cent), mild and recovered spontaneously. Felbinac is an effective management for acute soft tissue injuries and because of its topical application may be safer than oral non-steroidal anti-inflammatory drugs for the treatment of these conditions.

Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Middle Aged; Phenylacetates; Randomized Controlled Trials as Topic; Wounds and Injuries