biphenylylacetic-acid and Rhinitis--Allergic--Perennial

biphenylylacetic-acid has been researched along with Rhinitis--Allergic--Perennial* in 1 studies

Other Studies

1 other study(ies) available for biphenylylacetic-acid and Rhinitis--Allergic--Perennial

Article	Year
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis. Bioorganic & medicinal chemistry letters, 2011, Nov-01, Volume: 21, Issue:21 Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D(2) receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing. Topics: Animals; Biological Availability; Disease Models, Animal; Dogs; Drug Discovery; Mice; Phenylacetates; Rats; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial	2011

Article

Year

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.

Bioorganic & medicinal chemistry letters, 2011, Nov-01, Volume: 21, Issue:21

Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D(2) receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing.

Topics: Animals; Biological Availability; Disease Models, Animal; Dogs; Drug Discovery; Mice; Phenylacetates; Rats; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial

2011