biphenyl-indanone-a and Schizophrenia

biphenyl-indanone-a has been researched along with Schizophrenia* in 2 studies

Reviews

1 review(s) available for biphenyl-indanone-a and Schizophrenia

Article	Year
Promise of mGluR2/3 activators in psychiatry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:1 Topics: Animals; Anxiety Disorders; Biphenyl Compounds; Drug Delivery Systems; Humans; Indans; Mental Disorders; Pyridines; Receptors, Metabotropic Glutamate; Schizophrenia; Sulfonamides	2009

Other Studies

1 other study(ies) available for biphenyl-indanone-a and Schizophrenia

Article	Year
Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19 We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of 5 and 23 (EC50=111 and 5 nM, respectively). Topics: Allosteric Regulation; Animals; Biphenyl Compounds; Brain Chemistry; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indans; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Structure-Activity Relationship; Tissue Distribution	2005

Article

Year

Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.

Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19

We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of 5 and 23 (EC50=111 and 5 nM, respectively).

Topics: Allosteric Regulation; Animals; Biphenyl Compounds; Brain Chemistry; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indans; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Structure-Activity Relationship; Tissue Distribution

2005