Page last updated: 2024-10-23

biperiden and Idiopathic Parkinson Disease

biperiden has been researched along with Idiopathic Parkinson Disease in 46 studies

Biperiden: A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
biperiden : A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.

Research Excerpts

ExcerptRelevanceReference
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."7.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)
"Bromocriptine (10mg/day) was the second dopaminergic therapy employed in the present work."5.28[L-dopa, biperiden and sebum excretion in Parkinson disease]. ( Villares, JC, 1989)
"We investigated the effect of an anticholinergic (biperiden) and a dopamine agonist (apomorphine) on tremor, rigidity, and akinesia in patients with idiopathic Parkinson's disease."5.09Reduction of Parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges. ( Poewe, W; Schelosky, L; Scholz, U; Schrag, A, 1999)
"We found that levodopa had a good effect on the amplitude of the resting tremor, while the effect of biperiden was weaker."5.09A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor. ( Milanov, I, 2001)
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."3.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)
"This outnumbered sales to patients with Parkinson's disease by >20 to 1."1.35The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study. ( Bramness, JG; Gjerden, P; Slørdal, L, 2009)
"In 14 of the patients with Parkinson's disease, the symptoms were evaluated using conventional scales (UPDS, NYPDS, NWPDS, Schwab and England, and Hoehn and Yahr scale)."1.29Neurotransmitter levels in cerebrospinal fluid in relation to severity of symptoms and response to medical therapy in Parkinson's disease. ( Aceves, J; Flores, G; Ondarza, R; Velasco, F; Velasco, M, 1994)
"A 64-year-old man was diagnosed to have Parkinson's disease when aged 42 years and since then has been treated with levodopa and benserazide (up to 875 mg daily)."1.29[Bromocriptine-induced pleuropneumopathy]. ( Eberli, F; Greminger, P; Schmid, PA; Speich, R; Suter, T, 1994)
"In patients with Parkinson's disease L-dopa prolonged the silent period after transcranial brain stimulation and after ipsilateral cortical stimulation."1.29Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism. ( Accornero, N; Berardelli, A; Inghilleri, M; Manfredi, M; Priori, A, 1994)
"Bromocriptine (10mg/day) was the second dopaminergic therapy employed in the present work."1.28[L-dopa, biperiden and sebum excretion in Parkinson disease]. ( Villares, JC, 1989)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199035 (76.09)18.7374
1990's9 (19.57)18.2507
2000's2 (4.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gjerden, P1
Bramness, JG1
Slørdal, L1
GERSTENBRAND, F1
TSCHABITSCHER, H1
STEINBRECHER, W1
DRUEN, MA1
TIMBERLAKE, WH1
SCHWAB, RS1
ENGLAND, AC1
GILLHESPY, RO1
MUSTARD, DM1
ROSEN, A1
BROSCH, H1
DI CRISTO, G1
PIRO, S1
SCARPELLINO, F1
LERNER, PF1
O'DOHERTY, DS1
EDWARDS, CE1
Aebert, K1
Puntoni, U1
Kehr, W1
Pavoncello, S1
Di Bianco, V1
Di Castro, A1
Caviglia, A1
Cellitti, M1
Ondarza, R1
Velasco, F1
Velasco, M1
Aceves, J1
Flores, G1
Zappia, M1
Montesanti, R1
Colao, R1
Quattrone, A1
Linazasoro, G1
Schmid, PA1
Suter, T1
Speich, R1
Eberli, F1
Greminger, P1
Priori, A1
Berardelli, A1
Inghilleri, M1
Accornero, N1
Manfredi, M1
Nishiyama, K1
Mizuno, T1
Sakuta, M1
Kurisaki, H1
Shan, DE1
Kwan, SY1
Ho, HH1
Su, MS1
Schrag, A1
Schelosky, L1
Scholz, U1
Poewe, W1
Milanov, I1
Postma, JU1
Van Tilburg, W1
Gerlach, J2
Thorsen, K1
Schneider, E1
Jacobi, P1
Maxion, H1
Parkenberg, H1
Carlsson, M1
Svensson, A1
Carlsson, A1
Villares, JC1
Kurlan, R1
Como, P1
Mano, T1
Birket-Smith, E1
Kline, NS1
Mason, BT1
Winick, L1
Barolin, GS1
Rupprecht, A1
Jurna, I2
Krieger, H1
Nell, T1
Schreyer, I1
Simpson, GM2
Beckles, D1
Isalski, Z1
Lee, JH1
Orlov, P1
Kasparian, G1
DiMascio, A1
Cole, JO1
Sugano, H1
Takeya, T1
Strang, RR1
Boman, K1
Meurman, T1
Kurland, AA1
Dim, BH1
Olsson, JE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Kinematic Characterization of Upper Limb Parkinson's Disease Tremor for Optimized Botulinum Toxin Type A Therapy[NCT02668497]Phase 250 participants (Anticipated)Interventional2016-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for biperiden and Idiopathic Parkinson Disease

ArticleYear
[Drug research on norbornan derivatives. 2].
    Arzneimittel-Forschung, 1968, Volume: 18, Issue:3

    Topics: 1-Propanol; Acids; Alcohols; Amines; Amino Alcohols; Analgesics; Anesthetics, Local; Animals; Anti-I

1968

Trials

9 trials available for biperiden and Idiopathic Parkinson Disease

ArticleYear
Usefulness of movement time in the assessment of Parkinson's disease.
    Journal of neurology, 1994, Volume: 241, Issue:9

    Topics: Adult; Aged; Biperiden; Female; Functional Laterality; Humans; Levodopa; Male; Middle Aged; Movement

1994
Reduction of Parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges.
    Movement disorders : official journal of the Movement Disorder Society, 1999, Volume: 14, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Apomorphine; Biperiden; Cholinergic Antagonist

1999
A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor.
    Parkinsonism & related disorders, 2001, Volume: 8, Issue:1

    Topics: Aged; Antiparkinson Agents; Biperiden; Cross-Over Studies; Electromyography; Female; Humans; Levodop

2001
The movement pattern of oral tardive dyskinesia in relation to anticholinergic and antidopaminergic treatment.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:1

    Topics: Adult; Aged; Biperiden; Cheek; Clinical Trials as Topic; Humans; Methyltyrosines; Middle Aged; Mouth

1976
[Neuropsychological investigations on short-time effects of biperiden (Akineton) in Parkinson's Disease (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1975, Dec-23, Volume: 221, Issue:1

    Topics: Affect; Biperiden; Drug Evaluation; Humans; Motor Skills; Parkinson Disease; Piperidines; Reaction T

1975
Biperiden (Akineton): effective prophylactic and therapeutic anti-parkinsonian agent.
    Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:8

    Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Biperid

1974
Some methodological considerations in the evaluation of drug-induced extrapyramidal disorders: a study of Ex10-029, a new morphanthridine derivative.
    The Journal of clinical pharmacology and new drugs, 1972, Volume: 12, Issue:4

    Topics: Adult; Antiparkinson Agents; Basal Ganglia Diseases; Biperiden; Chronic Disease; Clinical Trials as

1972
Controlled studies of antiparkinsonism agents in the treatment of drug-induced extrapyramidal sympttoms.
    Acta psychiatrica Scandinavica. Supplementum, 1970, Volume: 212

    Topics: 1-Propanol; Adult; Biperiden; Clinical Trials as Topic; Handwriting; Humans; Male; Middle Aged; Neur

1970
Clinical evaluation of biperiden in Parkinson's disease.
    Diseases of the nervous system, 1967, Volume: 28, Issue:3

    Topics: Adult; Aged; Arteriosclerosis; Biperiden; Clinical Trials as Topic; Female; Humans; Male; Middle Age

1967

Other Studies

36 other studies available for biperiden and Idiopathic Parkinson Disease

ArticleYear
The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Cholinergic Antagoni

2009
[Experiences with the anti-parkinsonian drug akineton].
    Wiener klinische Wochenschrift, 1958, Apr-11, Volume: 70, Issue:15

    Topics: Biperiden; Cardiovascular Agents; Muscle Relaxants, Central; Parkinson Disease

1958
[Akineton psychoses].
    Deutsche medizinische Wochenschrift (1946), 1958, Aug-15, Volume: 83, Issue:33

    Topics: Biperiden; Cardiovascular Agents; Mental Disorders; Muscle Relaxants, Central; Parkinson Disease; Ps

1958
[Experiences with akineton in ambulant neurological practice].
    Munchener medizinische Wochenschrift (1950), 1959, Mar-06, Volume: 101, Issue:10

    Topics: Biperiden; Cardiovascular Agents; Databases, Genetic; Muscle Relaxants, Central; Parkinson Disease

1959
Biperiden (Akineton) in Parkinsonism.
    Archives of neurology, 1961, Volume: 5

    Topics: Biperiden; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders

1961
The value of biperiden alone and in combination with bamipine in the treatment of Parkinson's disease.
    The British journal of clinical practice, 1963, Volume: 17

    Topics: Anti-Allergic Agents; Biperiden; Histamine H1 Antagonists; Humans; Parasympatholytics; Parkinson Dis

1963
[Drug-induced parkinsonism and its treatment with Akineton].
    Therapeutische Umschau. Revue therapeutique, 1963, Volume: 20

    Topics: Biperiden; Humans; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders; Tranquilizing Agen

1963
[Report on the use of Akineton in reserpineinduced Parkinsonoid states].
    Die Medizinische Welt, 1963, May-04, Volume: 18

    Topics: Biperiden; Parasympatholytics; Parkinson Disease; Reserpine

1963
[Akineton in neurologic therapy with special reference to various forms of parkinsonism].
    Wiener medizinische Wochenschrift (1946), 1963, May-11, Volume: 113

    Topics: Biperiden; Humans; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders

1963
Use of biperiden hydrochloride in Parkinson's disease.
    Southern medical journal, 1960, Volume: 53

    Topics: Biperiden; Humans; Parkinson Disease; Trihexyphenidyl

1960
Akineton in the treatment of parkinsonism.
    The Medical annals of the District of Columbia, 1960, Volume: 29

    Topics: Biperiden; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders

1960
[What success does L-Dopa have in the treatment of parkinsonian akinesia?].
    Deutsche medizinische Wochenschrift (1946), 1967, Mar-17, Volume: 92, Issue:11

    Topics: Aged; Biperiden; Blood-Brain Barrier; Desipramine; Dihydroxyphenylalanine; Dopa Decarboxylase; Femal

1967
[Use of biperiden in delayed-release form in the treatment of Parkinson's disease and parkinsonian syndromes of various etiologies. Clinical experiments].
    La Clinica terapeutica, 1983, Oct-15, Volume: 107, Issue:1

    Topics: Adult; Aged; Biperiden; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male; Middle A

1983
[Drug therapy of Parkinson disease and parkinson disease-like symptoms].
    Arzneimittel-Forschung, 1981, Volume: Suppl 27

    Topics: Adenylyl Cyclases; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biperiden; Brain; Catechol O-Methy

1981
[Neurological aspects and modern trends in therapy of Parkinson's disease].
    La Clinica terapeutica, 1980, Feb-29, Volume: 92, Issue:4

    Topics: Atropine; Biperiden; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Procyclidine; Trihexyp

1980
Neurotransmitter levels in cerebrospinal fluid in relation to severity of symptoms and response to medical therapy in Parkinson's disease.
    Stereotactic and functional neurosurgery, 1994, Volume: 62, Issue:1-4

    Topics: Adult; Aged; Biperiden; Carbidopa; Evaluation Studies as Topic; Humans; Levodopa; Middle Aged; Neuro

1994
Anticholinergics and dyskinesia.
    Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:6

    Topics: Aged; Biperiden; Carbidopa; Drug Combinations; Drug Therapy, Combination; Dyskinesia, Drug-Induced;

1994
[Bromocriptine-induced pleuropneumopathy].
    Deutsche medizinische Wochenschrift (1946), 1994, Nov-11, Volume: 119, Issue:45

    Topics: Benserazide; Biperiden; Bromocriptine; Humans; Levodopa; Lung Diseases; Male; Middle Aged; Parkinson

1994
Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism.
    Brain : a journal of neurology, 1994, Volume: 117 ( Pt 2)

    Topics: Adult; Aged; Biperiden; Brain; Electric Stimulation; Evoked Potentials; Female; Humans; Levodopa; Ma

1994
Chronic dementia in Parkinson's disease treated by anticholinergic agents. Neuropsychological and neuroradiological examination.
    Advances in neurology, 1993, Volume: 60

    Topics: Aged; Biperiden; Blood Glucose; Brain; Cerebral Cortex; Dementia; Energy Metabolism; Female; Humans;

1993
Belly dystonia induced by levodopa and biperiden in a case of suspected multiple-system atrophy.
    Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:4

    Topics: Abdominal Muscles; Aged; Antiparkinson Agents; Autonomic Nervous System Diseases; Biperiden; Dose-Re

1996
Visual hallucinations and delirium during treatment with amantadine (Symmetrel).
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:5

    Topics: Aged; Amantadine; Benztropine; Biperiden; Delirium; Drug Eruptions; Female; Hallucinations; Humans;

1975
The relationship between parkinsonism and tardive dyskinesia.
    The American journal of psychiatry, 1977, Volume: 134, Issue:7

    Topics: Age Factors; Aminobutyrates; Baclofen; Basal Ganglia; Biperiden; Choline; Dopamine; Dyskinesia, Drug

1977
[Treatment of parkinsonism].
    Ugeskrift for laeger, 1976, Apr-26, Volume: 138, Issue:18

    Topics: Amantadine; Benztropine; Biperiden; Humans; Levodopa; Orphenadrine; Parkinson Disease; Procyclidine;

1976
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilp

1991
[L-dopa, biperiden and sebum excretion in Parkinson disease].
    Arquivos de neuro-psiquiatria, 1989, Volume: 47, Issue:1

    Topics: Aged; Aged, 80 and over; Aromatic-L-Amino-Acid Decarboxylases; Biperiden; Bromocriptine; Drug Therap

1989
Drug-induced alzheimerism.
    Archives of neurology, 1988, Volume: 45, Issue:3

    Topics: Aged; Alzheimer Disease; Biperiden; Carbidopa; Drug Combinations; Humans; Levodopa; Male; Parkinson

1988
[Dyskinesia induced by anticholinergic drugs--electrophysiological analysis].
    Rinsho shinkeigaku = Clinical neurology, 1974, Volume: 14, Issue:3

    Topics: Aged; Benztropine; Biperiden; Electromyography; Female; Humans; Male; Middle Aged; Movement Disorder

1974
Abnormal involuntary movements induced by anticholinergic therapy.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:6

    Topics: Aged; Biperiden; Dibenzazepines; Female; Humans; Mastication; Middle Aged; Movement Disorders; Orphe

1974
[Acute reversible Parkinson's syndrome in encephalitis].
    Wiener Zeitschrift fur Nervenheilkunde und deren Grenzgebiete, 1967, Volume: 25, Issue:1

    Topics: Acute Disease; Adult; Biperiden; Brain; Dopamine; Electroencephalography; Electromyography; Female;

1967
Reserpine rigidity in the rat--a model for the analysis of antiparkinson drugs.
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:2

    Topics: 1-Propanol; Animals; Biperiden; Cerebral Decortication; Electromyography; Methamphetamine; Models, N

1968
Motor disturbance induced by tremorine and oxotremorine.
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 267, Issue:1

    Topics: Acetylcholine; Amines; Animals; Atropine; Biperiden; Brain; Bridged-Ring Compounds; Chlorpromazine;

1970
Withdrawal of antiparkinson drugs.
    Archives of general psychiatry, 1971, Volume: 25, Issue:5

    Topics: Biperiden; Butyrophenones; Female; Humans; Male; Parasympatholytics; Parkinson Disease; Psychotic Di

1971
Measurement of body movement and its clinical application.
    The Japanese journal of physiology, 1970, Jun-15, Volume: 20, Issue:3

    Topics: Adult; Age Factors; Aged; Biperiden; Body Height; Body Weight; Cerebellar Ataxia; Circadian Rhythm;

1970
Investigations on the effect of some drugs on the Parkinsonian rigidity.
    Acta neurologica Scandinavica, 1970, Volume: 46, Issue:1

    Topics: Adult; Atropine; Biperiden; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Contr

1970
The effectiveness of parenteral administration of fluphenazine decanoate in the treatment of chronic schizophrenics.
    Diseases of the nervous system, 1970, Volume: 31

    Topics: Administration, Oral; Adult; Biperiden; Chronic Disease; Female; Fluphenazine; Humans; Infusions, Pa

1970