biperiden has been researched along with Disease Models, Animal in 18 studies
Biperiden: A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
biperiden : A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to elucidate the neural mechanisms of delirium, we administered the anticholinergic drug, biperiden (40 mg/kg i." | 7.73 | Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study. ( Chiba, S; Ishimaru, Y; Ishimoto, T; Tabata, K; Takasaki, H; Tamura, Y, 2006) |
| "In order to elucidate the neural mechanisms of delirium, we administered the anticholinergic drug, biperiden (40 mg/kg i." | 3.73 | Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study. ( Chiba, S; Ishimaru, Y; Ishimoto, T; Tabata, K; Takasaki, H; Tamura, Y, 2006) |
| "The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model." | 3.70 | Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication. ( McDonough, JH; Shih, TM, 2000) |
| "Donepezil was able to fully reverse the effects of biperiden on N50 sensory gating, but had residual effects when combined with scopolamine; i." | 1.39 | Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats. ( Blokland, A; Klinkenberg, I; Sambeth, A, 2013) |
| "When biperiden was combined with SKF-82958, contraversive circling also was enhanced and ipsiversive circling decreased." | 1.35 | Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions. ( Domino, EF; Ni, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Bittencourt, S | 1 |
| Ferrazoli, E | 1 |
| Valente, MF | 1 |
| Romariz, S | 1 |
| Janisset, NRLL | 1 |
| Macedo, CE | 1 |
| Antonio, BB | 1 |
| Barros, V | 1 |
| Mundim, M | 1 |
| Porcionatto, M | 1 |
| Aarão, MC | 1 |
| Miranda, MF | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Longo, BM | 1 |
| Mello, LE | 1 |
| Popelíková, A | 1 |
| Bahník, Š | 1 |
| Lobellová, V | 1 |
| Svoboda, J | 1 |
| Stuchlík, A | 1 |
| Hailwood, JM | 1 |
| Heath, CJ | 1 |
| Phillips, BU | 1 |
| Robbins, TW | 1 |
| Saksida, LM | 1 |
| Bussey, TJ | 1 |
| Szczodry, O | 1 |
| van der Staay, FJ | 1 |
| Arndt, SS | 1 |
| Domino, EF | 2 |
| Ni, L | 1 |
| Klinkenberg, I | 2 |
| Blokland, A | 2 |
| Asth, L | 1 |
| Lobão-Soares, B | 1 |
| André, E | 1 |
| Soares, Vde P | 1 |
| Gavioli, EC | 1 |
| Sambeth, A | 1 |
| Hamann, M | 1 |
| Meisler, MH | 1 |
| Richter, A | 1 |
| Tamura, Y | 1 |
| Chiba, S | 1 |
| Takasaki, H | 1 |
| Tabata, K | 1 |
| Ishimaru, Y | 1 |
| Ishimoto, T | 1 |
| Kovacic, B | 1 |
| Kehr, W | 1 |
| Shih, TM | 1 |
| McDonough, JH | 1 |
| Yoshida, K | 1 |
| Takahashi, H | 1 |
| Sato, K | 1 |
| Higuchi, H | 1 |
| Shimizu, T | 1 |
| Carlsson, M | 1 |
| Svensson, A | 1 |
| Carlsson, A | 1 |
| Tan, U | 1 |
| Gepdíremen, A | 1 |
| Banoglu, N | 1 |
| Kutlu, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for biperiden and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Biperiden; Cognitive Dysfunction; Disease Models, Anim | 2018 |
Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.
Topics: Animals; Antipsychotic Agents; Apathy; Behavior, Animal; Biperiden; Cognitive Dysfunction; Disease M | 2019 |
Modelling Alzheimer-like cognitive deficits in rats using biperiden as putative cognition impairer.
Topics: Animals; Biperiden; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; M | 2014 |
Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Benza | 2008 |
A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment.
Topics: Animals; Behavior, Animal; Biperiden; Cognition Disorders; Disease Models, Animal; Dose-Response Rel | 2011 |
The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Biperiden; Diazepam; Disease Models, An | 2012 |
Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Biperiden; Cholinergic Neurons; Cholinesterase Inhibit | 2013 |
Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Brain; Diazepam; Disease Models, Animal | 2003 |
Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study.
Topics: Acetylcholine; Action Potentials; Animals; Behavior, Animal; Biperiden; Brain; Consciousness; Deliri | 2006 |
Monkey models of tardive dyskinesia.
Topics: Animals; Benztropine; Biperiden; Cebus; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Fl | 1983 |
[Drug therapy of Parkinson disease and parkinson disease-like symptoms].
Topics: Adenylyl Cyclases; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biperiden; Brain; Catechol O-Methy | 1981 |
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivator | 2000 |
Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Disease Models, Animal; Guanidines; Hal | 2000 |
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice.
Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilp | 1991 |
Intermittent tremor-bursts induced by chlorpromazine and pentobarbitone in guinea pigs: a new tremor model.
Topics: Acoustic Stimulation; Animals; Biperiden; Chlorpromazine; Disease Models, Animal; Guinea Pigs; Muscl | 1991 |